Summary Comparison of HIV-1 Protease versus Renin Structure-Based Design

4 Summary Comparison of HIV-1 Protease versus Renin Structure-Based Design 

The capability to communicate 3D structural studies with the chemists and other researchers has evolved significantly [80]. Today in our laboratories, the use of a 3D projection room has advanced the HIV-1 protease inhibitor design to a team effort, in which creative design ideas can be discussed within a group in an extremely productive manner, while visualizing the protein/inhibitor interactions. 

In receptor structure-based design the operative word is structure. The success of the methodology is closely tied to the amount of structural information that is available. Although a receptor model derived from experimentally determined structures of homologous proteins is adequate, as was the case with renin, having an experimentally determined struc- 

3 Structure-Based Design From Renin to HIV-I Protease 

3 Structure-Based Design from Renin to HIV-1 Protease 

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