Sulfur mustards history

The studies of Nishimoto et al. (1988), Yamada (1974) and Inada et al., (1978) provide strong evidence for a causal link between chemical agent exposure and cancer however, because the workers were exposed to multiple chemicals, it is not possible to state conclusively that the cancers were due solely to sulfur mustard. Furthermore, it should be noted that several possible confounding factors, such as tobacco smoking habits, preexisting health conditions, and post-exposure occupational histories of the workers, were not evaluated. In addition, SMRs themselves may not provide an accurate estimate of relative cancer risk if they do not correlate with tumor incidence rates in exposed and control groups (i.e., if social/economic or other differences between control and exposed groups result in differences in health care which affect survival rates). 

Casillas, R.P., Kiser, R.C., 2000. Therapeutic approaches to dermatotoxicity by sulfurmustard. I. Modulation of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model. J. Appl. Toxicol. 20 (Suppl. 1), S145-S151. Coleman, K., 2005. A History of Chemical Warfare. Macmillan, New York, NY. Fitzgerald, G.J., 2008. Chemical warfare and medical response during World War I. Am. J. Public Health 98 (4), 611-625. 

Table 1.1 Timeline and history of Sulfur Mustard discovery and...

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