Sulfur-containing compounds synthesis

For a review of the use of phase-transfer catalysis to prepare sulfur-Containing compounds, see Weber, W.P. Gokel, G.W. Phase Transfer Catalysis in Organic Synthesis, Ref. 437, p. 221. 

Chiral Phosphorus and Sulfur-Containing Compounds in Asymmetric Synthesis. 

Also, Meier and Rumpf synthesized angular benzobisthietes 50 and 51 in moderate yields, by the dehydration of bis(hydroxymethyl)dimercaptobenzenes 83 and 84 (Scheme 14), which may be versatile reagents for synthesis of polycyclic sulfur-containing compounds <1998TL9639>. 

He studied the synthesis and utilization of sulfur-containing compounds in man, rat, dog, goat, cow, ewe, bacteria, yeasts, cockroach, and algae, constantly being aware that the results are good only as the methods which were employed to obtain them. He devoted a great deal of his time to the development of better and more refined chemical and chromatographic methods for the isolation and determination of amino acids in proteins from a variety of sources, and he had even set up a laboratory in his house for the purpose, where he worked at all hours. 

Compounds that contain elements other than carbon also undergo complete combustion to form stable oxides. For instance, sulfur-containing compounds undergo combustion to form sulfur dioxide, S02, a precursor to acid rain. Complete combustion reactions are often also synthesis reactions. Metals, such as magnesium, undergo combustion to form their most stable oxide, as shown in Figure 4.11. 

N-Acetyl-L-cysteine (NAC) is a natural sulfur-containing compound that is produced in living organisms from the amino acid cysteine. It is involved in the intracellular synthesis of a chemical called glutathione (or GSH). Cells (particularly liver cells)... 

Asymmetric sulfinyl transfer reactions are of significant interest, since they can be applied to the synthesis of chiral sulfur-containing compounds, which are valuable synthons for pharmaceuticals and natural products [46]. Moreover, chiral sulfoxides are versatile chiral auxiliaries for asymmetric organic synthesis. A number of studies... 

Interest in these studies arises from fundamental research where monolayers serve as models of biomimetic systems, as well as from important apphcations of such systems in molecular and bioelectronic devices, in sensors construchons, corrosion/inhibition phenomena, and synthesis of nanostructures ]93]. Although self-assembly processes of sulfur-containing compounds occur at the surfaces of many metals, especially the copper-group metals (Cu, Ag, Au), the most extensive studies have been... 

In 1995, sulfobacin A (158, Figure 6.19) and B (159), von Willebrand factor receptor antagonists, were isolated by Kamiyama et al. from the culture broth of a terrestrial bacterium Chryseobacterium sp. In the same year, the isolation of flavocristamide A (160) and B (=sulfobacin A, 158), DNA polymerase a inhibitors, from the cultured mycelium of marine bacterium Flavobacterium sp. in Hokkaido was reported by Kobayashi et al. These are sulfonolipid, and unusual sphingosine derivatives. We became interested in synthesizing these three sulfur-containing compounds, and carried out their synthesis from L-cysteine.23,24... 

Inorganic sulfate is the form of sulfur most commonly available in the physical environment for use by organisms. Plants utilize sulfate (oxidation state +6) as their sulfur source for the synthesis of the many sulfur-containing compounds essential for life. Most of these compounds, including cysteine, methionine, and GSH, contain sulfur in oxidation state -2. Plants must therefore effect the reduction of sulfate in an 8c reduction. Reduction of sulfate by plants quantitatively accounts for most biological sulfate reduc-... 

In the nonprotein fraction reduced glutathione, GSH, is ubiquitous, and is commonly a mqjor constituent (Table I). The soluble fraction of plants also includes a variety of other sulfur-containing compounds that are normally present in relatively small amounts (a) Intermediates on the route to protein cysteine and protein methionine, such as cysteine, cystathionine, homocysteine, and methionine, (b) Compounds involved in methyl transfer reactions and polyamine synthesis AdoMet.t AdoHcy, and, presumably, 5 -methyl-thioadenosine. The biochemistry of the compounds in both groups (a) and (b) will be discussed here, (c) Compounds clearly related metabolically to cysteine or methionine, such as 5-methylcysteine and 5-methylmethionine. Because in certain plants these derivatives comprise a major portion of the nonprotein sulfur amino acids, they will be discussed here, (d) A number of compounds of uncertain function, the biochemistry of which has often not been clarified. Discussion of such compounds (Richmond, 1973 Fowden, 1964) is beyond the scope of this chapter. 

---