Sulfoxide compounds

Nexium, A.85) is a single enantiomer of the chiral sulfoxide. Compounds A.83 through A.87 are prodrugs and rearrange to form an active species that irreversibly deactivates proton pumps. 

Urine Thiodiglycol sulfoxide Compound also present in nonexposed subjects (< 10 ng/ml) GC-MS Black and Read (1995) Riches et al. (2007)... 

Sulfoxides - Compounds having the structure R2S=0 (R not equal to H), e.g. Ph2S=0, diphenyl sulfoxide. [5]... 

Suitable polymerization catalysts are organic metal carboxylates. Lithium salts are highly soluble in the reaction system and large in the catal5 ic effect, but expensive. Potassium, rubidium, cesium, and alkatine earth metal salts are considered poorly soluble in the reaction system. Sodium salts can preferably be used since they are cheap and moderately soluble in the polymerization system. Thus, sodium acetate is a preferred catalyst. Another class of catalysts are cyclic amine compounds, A-heteroaromatic compounds, and organic sulfoxide compounds. 

In view of their interest in the stabilization in neutral bicyclic sulfoxide compounds El-Bergmi et al. performed B3LYP/6-3H-G calculations on 5-thiabicyclo[2.1.1]hex-2-ene 5-oxide derivatives. The GIAO method and AIM revealed a stabilization of the S atom with the double bond for the exo configuration, in agreement with the experimental results. 

Activated sulfoxides are well-known for use as electrophiles (Swem method). The polymerization of the sulfoxide compound is initiated via the sulfonium cation as an active species by the protonation on the oxygen of the sulfoxide bond. The active species electrophilically substitutes on the benzene ring to eliminate water. 

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