Thiodiglycol sulfoxide

Until recently, another clear advantage of GC/MS has been the lower limits of detection that are generally achievable for trace analysis. Examples are thiodiglycol, thiodiglycol sulfoxide, and methyl alkylphosphonic acids. GC capillary columns usually provide sharp narrow peaks, and techniques such as NICI in combination with fluorinated derivatives are inherently extremely sensitive. However, the latest generation of LC/MS/MS instruments, including some ion traps, triple sector quadrupole and TOF systems, are at least an order of magnitude more sensitive than their predecessors and may eventually provide equally low limits of detection. In terms of initial cost, they are still likely to be more expensive than GC/MS instruments. 

In dilute solution, the primary hydrolysis product of sulfur mustard is thiodiglycol (TDG) (Figure 12). In the environment, TDG may be oxidized to its thiodiglycol sulfoxide (TDGO), and more rarely to the sulfone, though the latter may be an important... 

R. Black, I. Holden and M. Reid, Derivatisation reactions of thiodiglycol and thiodiglycol sulfoxide, Proceedings of the Seventh International Symposium on Protection Against Chemical and Biological Warfare Agents, Stockholm, 15-19 June, 2001. 

R.M. Black and R.W. Read, Methods for the analysis of thiodiglycol sulfoxide, a metabolite of sulfur mustard, in urine using gas chromatography-mass spectrometry, J. Chromatogr., 558, 393-404 (1991). 

It is worth noting that background levels of thioglycol and thiodiglycol sulfoxide have been found in the urine of healthy individuals never exposed to sulfur mustard. For this reason their validity as unambiguous markers for sulfur mustard exposure has been questioned. Black and Read (1995) suggested the determination of P-lyase pathway metabolites which in the urine of exposed patients were found at concentrations similar to those of thiodiglycol sulfoxide, but were not found in unexposed individuals. 

Urine Thiodiglycol sulfoxide Compound also present in nonexposed subjects (< 10 ng/ml) GC-MS Black and Read (1995) Riches et al. (2007)... 

Thiodiglycol sulfoxide 1,4-Thioxane Trinitrotoluene (TNT) Triphenyl arsine ... 

Dithiane Thiodiglycol Thiodiglycol sulfoxide Thiodiglycol sulfone... 

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