Sulfamic cyclohexyl

The A/-alkyl and W-cyclohexyl derivatives of sulfamic acid are comparatively stable. The A/-aryl derivatives are very unstable and can only be isolated ia the salt form. A series of thia2olylsulfamic acids has been prepared. 

It was further found that substitution of a methyl group at C-1 of either cyclohexyl- or cycloheptyl-sulfamate destroys the sweetness of these compounds.. -(l-Adamantyl)sulfamate (107), which possesses an imino hydro-... 

Fig. 29.—Newman Projection along the N-S Bond for Saccharin and Two Cyclohexyl-sulfamates. ...

SODIUM CYCLOHEXYL SULFAMATE see SGCOOO SODIUM CYCLOHEXYL SULFAMIDATE see SGCOOO SODIUM CYCLOHEXYL SULPHAMATE see SGCOOO SODIUM-2,4-D see SGH500 SODIUM DALAPON see DGI600 SODIUM DBDT see SGF500 SODIUM DECYLBENZENESULFONAMIDE see DAJOOO... 

Cyclamic acid is made by the sulfonation of cyclohexyl-amine. Cyclohexylamine is a six-carbon ring compound with a single amine (NH2) group attached to it. Its formula is CeHuNH. Sulfonation is the process by which an -S02 group is added to a compound. Sulfonation of cyclohexylamine is accomplished with either sulfur dioxide (S02) or sulfamic acid (H0S02NH2). 

Alkyl dimethyl ethylbenzyl ammonium cyclohexyl sulfamate. See Quaternium-8 Alkyl dimethyl hydroxyethyl ammonium... 

Synonyms Calcium cyclohexanesulfamate Calcium cyclohexyl sulfamate Cyclamate calcium Cyclamate, calcium salt Cyclamic acid calcium salt Cyclamic acid hemicalcium salt Cyclohexanesulfamic acid calcium salt ... 

Calcium cyclohexanesulfamate Calcium cyclohexyl sulfamate. See Calcium cyclamate Calcium diacetate... 

Sodium iV-cyclohexyl sulfamate (cycliunate, 141 R = cyclohexyl) was introduced as a non-nutritive artificial sweetener in 1939. It is 30 times sweeter than sucrose, but was banned in the USA and Canada in 1970 because rats fed with large doses developed bladder cancer, although it is permitted in many other countries. Cyclohexylammonium sulfamate, an intermediate in the manufacture of non-nutritive sweeteners, may be prepared by reaction of cyclohexylamine (two to three equivalents) with chlorosulfonic acid in trichloroethene at 60-75 C the presence of the excess amine avoids an acidic medium and side reactions. A-Cyclohexylsulfamic acid has been obtained by treatment of cyclohexylamine with a mixture of sulfur trioxide and chlorosulfonic acid in trichloroethene at < 60 Cyclamate can also be manufactured by heating cyclohexylamine with sulfamic acid in xylene at 132-139 Benson and Spillane discussed the... 

In A-substituted sulfamic acids, exceptional sweetness was discovered to be generally limited to those members containing a cyclohexyl ring which may be substituted, a free hydrogen atom attached to the nitrogen atom and almost any salt-forming group (X) as shown 142. ... 

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