Sulfadimethoxine pharmacokinetics

In other cases, the same disease states exert a different effect on drug pharmacokinetics depending on the drug and the animal species (41). Elimination of sulfadimethoxine or amoxycillin from pigeons was distinctly accelerated in case of Coccidia (42) or Salmonella infection (43). However, significant differences in the residue profile, compared to healthy chickens, were observed neither in that of sulfamethazine nor in that of its acetyl metabolite after oral administration to chickens infected with Coccidia (44). 

Lobster. Studies have been conducted to determine the pharmacokinetics of excretion, and the oral bioavailability of several drugs in adult lobsters of both sexes. Sulfadimethoxine and ormetoprim, which are used as a drug combination to treat various bacterial diseases, were studied separately and together. The usual dose ratio of the sulfadimethoxine ormetoprim combination is 42 4 mg/kg. Preliminary studies of the hemolymph concentration, and the tissue distribution at various times after intravascular and oral doses, were conducted with erythromycin, 50 mg/kg, in the free base form. Studies of the fate of phenol were conducted after intravascular administration of several doses. 

Sulfadimethoxine. The pharmacokinetics of elimination of the intravascularly administered sodium sulfadimethoxine were independent of dose in the range 21 to 55 mg/kg, and the elimination of half life of parent sulfadimethoxine from hemolymph was 77 hours (69). Binding of sulfadimethoxine to hemolymph proteins was dose independent in the range 14 to 203 M-g/ml, and was 53% bound (69). In the intermoult, gonadally regressed lobsters used in the study, there was no sex difference in drug elimination (69). The rate of absorption of orally administered sulfadimethoxine, 42 mg/kg, was... 

Mengelers, M.J.B. Oorsprong, M.B.M. Kuiper, H.A. Aerts, M.M..L. Van Gogh, E.R. Van Miert, A.S.J.P.A.M. Determination of sulfadimethoxine, sulfamethoxazole, trimethoprim and their main metabolites in porcine plasma by column switching HPLC. J.Pharm.Biomed.Anal., 1989, 7, 1765-1776 Tu, Y.-H. Allen, L.V., Jr. Fiorica, V.M. Albers, D.D. Pharmacokinetics of trimethoprim in the rat. J.Pharm.ScL, 1989, 78, 556-560 [plasma brain heart lung liver spleen kidney prostate testicles seminal vesicles LOD 100 ng/mL chlorphenesin carbamate pharmacokinetics]... 

Righter HF, Showalter DH, Teske RH, Pharmacokinetic study of sulfadimethoxine depletion in suckling and growing-pigs. Am. J. Vet. Res. 1979 40 713-715. 

Mengelers MJB, Vangogh ER, Kuiper HA, Pijpers A, Verheijden JHM, Vanmiert ASJPAM, Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after intravenous administration to healthy and pneumonic pigs, J. Vet. Pharmacol. Ther. 1995 18 243-253. 

Barrett J (1981) Biochemistry of parasitic helminths, Macmillan, London Barrett J, Beis I (1982) Catalase in free-living and parasite platyhelminths. Experientia 38 536 Barron MG, Gedutis C, James MO (1988) Pharmacokinetics of sulphadimethoxine in the lobster, Homarus americanus, following intrapericardial administration. Xenobiotica 18 269-276 Barron MG, James MO (1988) Fate of sulfadimethoxine in the lobster, Homarus americanus. Mar Env Res 24 85-88... 

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