Sulfa drugs history

Sulfa drug allergy Probenecid is a sulfonamide patients with a history of allergy to sulfa drugs may react to probenecid. 

A 55-year-old non-alcoholic obese woman, who was allergic to sulfa drugs, presented with a 5-day history of jaundice, malaise, and a pruritic rash that began 3 weeks after she started to take celecoxib 200 mg/day for radicular pain (7). There were marked increases in liver enzymes and bilirubin and a peripheral eosinophi-lia. Liver biopsy showed marked intrahepatocyte cholestasis with eosinophil-rich inflammation, consistent with a drug reaction. Her symptoms and laboratory abnormalities completely resolved after withdrawal of celecoxib but took a long time (4 months) to normalize. 

A 17-year-old boy with a history of sulfa allergy is diagnosed with left-side ulcerative colitis after a 3-week history of bloody diarrhea and tenesmus. On examination he is afebrile and has no abdominal tenderness. The appropriate drug therapy to institute initially is which of the following ... 

There are many other examples. A study on allergic reactions to sulfa-based dmgs lists 38 sulfonamide nonantibiotic drugs. Based on the rich history of heterocycles in medicine, it is not surprising that sulfonamides dominate to this day. 

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