Substrate binding energy

The mechanism of action of lysozyme has been suggested to involve strain in the substrate as a result of binding to the protein.31 The protein requires that the substrate binds to the protein in a distorted state that is close to the transition state of the reaction. The energy for this distortion can arise from the substrate binding energy. This example differs from the entatic state hypothesis because this strain arises from substrate binding and is not a feature of the protein structure. However, the entatic state... 

Metal Ion Catalysis Metals, whether tightly bound to the enzyme or taken up from solution along with the substrate, can participate in catalysis in several ways. Ionic interactions between an enzyme-bound metal and a substrate can help orient the substrate for reaction or stabilize charged reaction transition states. This use of weak bonding interactions between metal and substrate is similar to some of the uses of enzyme-substrate binding energy described earlier. Metals can also mediate oxidation-reduction reactions by reversible changes in the metal ion s oxidation state. Nearly a third of all known enzymes require one or more metal ions for catalytic activity. 

Hexokinase provides an excellent example of induced fit as a means of using substrate binding energy. 

A. Utilization of enzyme—substrate binding energy in catalysis4... 

Table 1 Results for the reaction of gas-phase H with H atoms adsorbed onto model substrates, for several values of the H-substrate binding energy, Z)a.

S mean binding energy of Meads on S step binding energy of Meads at a step atom-substrate binding energy lateral interaction parameter angular frequency, lateral interaction parameter deposition frequency of atoms to a site x dissolution frequency of atoms from a site x phonon frequency area of an adsorption site... 

Substrates titanium oxide and titanium metal coatings on silicon substrates. Binding energy shift relative to main peak component. 

Some information about catalysts can be obtained by TPD techniques. The types of active sites on the surface can be determined by the number of desorption peaks the adsorption strength (adsorbate-substrate binding energies) can be obtained by the maximum desorption temperature of the desorption peaks, and the... 

Element Substrate Binding Energy (eV) Cohesive Energy (eV)... 

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