Substitutions of Heteroaromatic Bases by Nucleophilic Carbon Free Radicals

Substitutions of Heteroaromatic Bases by Nucleophilic Carbon Free Radicals [Pg.17]

The substitutions with nucleophilic radicals become particularly interesting only with electron-deficient aromatic substrates, as the ionic nucleophilic substitutions. Carbon free radicals are the most common nucleophilic radicals and they are obviously among the most important organic free radicals. Heteroaromatic bases on the other hand are electron-deficient aromatic substrates which readily react with nucleophilic species. The protonation of heteroaromatic bases strongly increases their electron-deficient nature and therefore the reactivity towards nucleophilic reagents, while the reactivity towards electrophilic species is strongly [Pg.17]