Substance P receptor

Tachykinin NH receptor TK N r Neurokinin-1 receptor, substance P receptor... 

Hill, R (2000) NKl (substance P) receptor antagonists—why are they not analgesic in humans Trends Pharmacol. Sci. 21 244 246. 

Malcolm MacCoss, Christopher J. Swain, Timothy Harrison, Raymond G. Hill, Franz Hefti, Edward M. Scolnick, Margaret A. Casderi, Gary G. Chicchi, Sharon Sadowski, Angela R. Williams, Louise Hewson, David Smith, Emma J. Carlson, Richard J. Hargreaves and Nadia M. J. Rupniak, Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors , Science 281 (1998) 1640-45 Kuhn, Roland, Artistic Imagination and the Discovery of Antidepressants , Journal of Psychopharmacology 4, no. 3 (1990) 127-30... 

Herpfer I and Lieb K (2003). Substance P and substance P receptor antagonists in the pathogenesis and treatment of affective disorders. World Journal of Biological Psychiatry, 4, 56-63. 

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998 281 1640-1645. 

Granas, C., Ferrer, J., Loland, C. J., Javitch, J. A. and Gether, U. N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. /. Biol. Chem. 278 4990-5000, 2003. 

Neuropeptide receptors are not confined to synaptic regions. Peptidergic neurotransmission often operates on a slower time scale than conventional neurotransmitters, so it is not surprising that peptide receptors are often localized at a distance from the synapse. For example, although some substance P terminals contact membranes loaded with substance P receptor, only a small fraction of the substance P receptor-laden membrane is apposed to synaptic terminals. Substance P may diffuse a considerable distance from its release site and still find a receptor with which it can interact [21]. 

S. W. Huskey, D. Luffer-Atals, B. J. Dean, E. M. McGowan, W. P. Feeney, S. H. Lee Chiu, Substance P Receptor Antagonist I Conversion of Phosphoramidate Prodrug after i.v. Administration to Rats and Dogs , Drug Metab. Dispos. 1999, 27, 1367- 1373. 

Quirion R, Shults CW, Moody TW, Pert CB, Chase TN, O Donohue TL. (1983). Autoradiographic distribution of substance P receptors in rat central nervous system. Nature. 303(5919) 714-16. 

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snovely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, HiU RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Rupniak NMJ (1998) Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281 1640-1645 Landgraf R (1995) Intracerebrally released vasopressin and oxytocin measurement, mechanisms and behavioral consequences. J Neuroendocrinol 7 243-253 Landgraf R, Neumann I (2004) Vasopressin and oxytocin release within the brain a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol 25 150-176... 

Rupniak, N.M., Kramer, M.S. Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists. Trends Pharmacol. Sci. 20, 485-490,... 

Iwashita, T., Shimizu, T. Imipramine inhibits intrathecal substance P induced behavior and blocks spinal cord substance P receptors in mice, Brain Res. 1992, 581, 59-66. 

Caesar, M., Seabrook, G. R., Kemp, J. A. Block of voltage-dependent sodium currents by the substance P receptor antagonist CP96.345 in neurones cultured from rat cortex, Br. J. Pharmacol. 1993, 109, 918-924. 

Garcia, M., Sakamoto, K., Shigekawa, M., Nakanishi, S., Ito, S. Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor, Biochem. Pharmacol. 1994, 48, 1735-1741. 

Mitsuhashi, M., Ohashi, Y., Shichijo, S., Christian, C., Sudduth, K. J., Harrowe, G., Payan, D. G. Multiple intracellular signaling pathways of the neuropeptide substance P receptor, J. Neurosci. Res. 

Mochizuki, O. N., Nakajima, Y., Nakanishi, S., Ito, S. Characterization of the substance P receptor-mediated calcium influx in cDNA transfected Chinese hamster ovary cells. A possible role of inositol 1,4,5-triphosphate in calcium influx, J. Biol. Chem. 1994, 269, 9651-9658. 

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