Sublethal damage repair

Heimburger DK, Shewach DS, Lawrence TS. The effect of fluorodeoxyuridine on sublethal damage repair in human colon cancer cells, lnt J Radiat Oncol Biol Phys 1991 21 983-987. 

Diagram of the peripheral thermal damage after ablative laser treatment. The number of lethal lesions is proportional to the degree of shading. The skin is repaired from peripheral keratinocytes some have suffered sublethal damage. Heat-shock protein (HSP) inducers help improve keratinocyte resistance to heat shock. 

Where there is sublethal damage, or very light damage, the cells must eliminate or repair the damaged and ineffective proteins, increase protection of the proteins that did... 

The effects of acute and chronic exposure may be either lethal or sublethal. Pairing off a building is an example of an acute stress. It may be fatal, but it need not be. It may produce sublethal damage, srrch as broken bones, which the body repairs within a short time. It may also produce sublethal adverse effects, such as damage to the brain or spinal cord, which the body is imable to repair. The effect of eating fish with a high concentration of mercury for many years is an example of a chronic stress. The effect may be fatal indeed some people have died fiom such... 

---