SUBJECTS ferric compounds

Kelsey SM, Hider RC, Bloor JR, et al. Absorption of low and therapeutic doses of ferric maltol, a novel ferric iron compound, in iron deficient subjects using a single dose iron absorption test. J Clin Pharm Ther 1991 16 117—122. 

Relatively few 2-pyrazolin-4-ones are known, and most of our knowledge of these compounds has been furnished by Chattaway, Ashworth and co-workers who published an extensive series of papers on this subject in the thirties. These compounds are basic, forming salts with acids and alkyl halides, and they are also acids, giving salts with bases. They form colored complexes with ferric chloride. Four structures are possible for 2-pyrazolin-4-one, (XXXVII), (XXXVIII), (XXXIX) and (XL), but substitution at C-3 and C-5 makes possible... 

There are many reports on the biogenetic synthesis of these alkaloids by phenol oxidation. These reactions were carried out using a diphenolic isoquinoline with one-electron oxidizing reagents ferric chloride, potassium ferricyanide, manganese dioxide, and so on. In order to obtain the androcymbine-type compound 82 the diphenolic isoquinoline 81 was subjected to phenol oxidation with potassium ferricyanide (3a) and with ferric chloride (2b), respectively, but instead the homo-aporphine 83 (2a) coupled at the ortho-ortho position to the hydroxy groups. 

---