Subject potential allergens

It is generally accepted (based on clinical and in vitro studies) that mast cells (and basophils), IgE and FceRI are involved in most cases of allergen-induced anaphylaxis in humans. However, it is difficult to define the exact roles and relative importance of mast cells, basophils, and other potential effector cells (e.g monocytes/macrophages, dendritic cells) in either IgE-dependent or IgE-independent human anaphylaxis. Unlike in mice, we neither have access to mast cell- or basophil-deficient humans nor can we genetically manipulate human subjects to produce such phenotypes. 

Blackcurrants are being studied in laboratory experiments to test for potential activity against heart disease, cancer, microbial infections, and neurological disorders such as Alzheimer s disease. In a 2008 study in Italy, blackcurrants were used in a nutraceutical product called Pantescal to study subjects allergic to common airborne allergens, revealing that allergy biomarkers were decreased by the treatment. 

Epoxy resins, hardeners, diluents, and acrylate compound glues are frequently present in the cabinet maker s shop (Kanerva et al. 1995b). A 1995 review of patch testing results in Helsinki showed that 6% of subjects showed a positive patch test to at least one of a series of plastic and glue allergens, emphasizing the sensitizing potential of these chemicals (Tarvainen... 

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