Subject poisoning, symptoms

Autopsy tissues and other biologic specimens from people fatally poisoned with endrin (by the oral or an unspecified route) were analyzed (Tewari and Sharma 1978). The "fatal period" (presumed to be the time from onset of symptoms until death) for the subjects studied ranged from 1 to 6 hours. As is characteristic of oral administration, highest tissue concentrations were observed in the stomach (1.04-14.5 mg/100 g), intestine (1.31-66 mg/100 g), and liver (0.94-20 mg/100 g), followed by kidney, spleen, heart, and lung. Blood concentrations were low (0.43-0.85 mg/100 g) compared to tissue concentrations. 

There has been only one report of industrial poisoning, a fatality caused by very high vapor inhalation in a small enclosure. The isomeric concentration of the vapor was not reported, nor were the level and duration of the exposure or symptoms of toxicity. In another early report, exposure to the trans isomer at 2200ppm caused nausea, drowsiness, fatigue, vertigo, and increased intracranial pressure in two human subjects. ... 

It is believed that metabolic products of TOCP inhibit acetylcholinesterase. Apparently other factors are involved in TOCP neurotoxicity. A study of tri-o-cresylphosphate poisoning in China has described a number of symptoms.4 Initial pain in the lower leg muscles was followed by paralysis and lower limb nerve injury. Patients with mild poisoning recovered after several months, but more severely poisoned ones suffered permanent effects. Despite the devastating effects of TOCP, the percentage of virtually complete recovery in healthy subjects is relatively high. 

Minor poisonings, which result from the handling of TXT or receptacles which are covered with the substance. The effects differ from TNT dermatitis in that the effects are internal as well as external. The symptoms are dizziness, headache and sometimes nausea. Men or women who are new to the work, and whoare not accustomed to being a round TN T, are especially subject to this form of poisoning from TNT. The stTnptoms usually disappear after the person becomes more accustomed to the presence of TNT. Cases have been known, however, where the poisoning has developed into a more serious form. 

I. Severe Poisonings. After the symptoms of a minor poisoning are displayed, there is a period in which the subject feels perfectly well, no effects of the TNT being noticeable. This neutral period may, in cases of extreme susceptibility, terminate in severe... 

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