Subject compounds, uses

This prompted us to develop a novel regioselective nitrosation procedure for resorcinol monoethers, e.g. for monobenzyl resorcinol, as starting material (Fig. (11)). Solid sodium nitrite in anhydrous propionic acid as solvent was an effective system for the completely regioselective nitrosation of the subject compounds. High yields of pure 2-nitroso products were obtained. Attack at the 4-position becomes only competitive in the presence of water in the solvent. Absence of water was ensured by addition of one percent of propionic anhydride. The excellent regioselectivity observed is obviously related to the presence of nitrosyl... 

In spite of the compounding of errors to which it is subject, the foregoing method was the best procedure for measuring reactivity ratios until the analysis of microstructure became feasible. Let us now consider this development. 

To illustrate the overall magnitude of the mechanistic problem, let us consider the varied reactivity of a prototypical carbonyl compound such as acetone, which is subject to many diverse reactions such as addition, substitution, cycloaddition, oxidation, reduction, etc., as illustrated in Chart 2. 

Stereochemistry continues to be a highly viable and prolific subject. Nonetheless, in 1993 the editors reluctantly decided to retire after publication of Volume 21, in part because for some time prior they had been fully occupied with the publication of Stereochemistry of Organic Compounds (Wiley, 1994). Sadly, my close friend, able coauthor and coeditor, and valued colleague Sam Wilen died soon thereafter. In as much as the explosive development in stereochemistry is continuing, I am delighted that Scott Denmark, who is eminently qualified for the task, has taken over editorship of the series with Volume 22.1 am particularly pleased to see a chapter by my fellow stereochemist Kurt Mislow in this volume, since Kurt helped us launch the series in 1967 by agreeing to be an editorial advisor and by coauthoring a seminal chapter on stereochemical relationships (heterotopicity) for... 

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