Subgroups interactions

So far the analysis has lead to the concept of a carrier space which links the degeneracy to a doubly transitive orbit of cosets of maximal subgroups. Interactions in this space are expressed as transition operators between the cosets. The final part of the treatment should bring in the vibrational degrees of freedom which are responsible for the Jahn-Teller activity. 

Model explorations, if conducted at all, should be justified with suitable a priori power and should be consistent with the principle of BE assessment. For example, effects of formulation by covariate interaction should not be tested, for the same reason that, in standard BE analysis, treatment by subgroup interaction is typically not tested. This implies that the number of explorations should be kept very small, and preferably avoided in general. 

Interactive LC systems are those where solute retention is predominantly controlled by the relative strengths of the molecular interactions between solute molecules with those of the two phases. In such systems, exclusion and entropically driven interactions will be minor contributions to retention. The three basically different types of molecular interaction, dispersive, polar and ionic give rise to three subgroups, each subgroup representing a separation where one specific type of interaction dominates in the stationary phase and thus governs solute retention. The subgroups are as follows ... 

The first subgroup best describes global molecular properties such as size, surface, volume, while the second subgroup describes more and more (as the order of index increases) local structural properties and possibly long-range interactions. 

The iron subgroup exhibits a plethora of nonclassical M H Si interactions both for mono- and dinuclear complexes. Iron in the high formal oxidation states IV and ruthenium in the high formal oxidation states IV-VI are particularly prone to form such species. Some of them having three or more hydrides will be discussed in Section IV. 

Vincristine resistance has been studied in Chinese hamster ovary cell lines cells resistant to vincristine also are resistant to vinblastine and vindesine. Suggestions were made that, in cells with relatively low levels of drug resistance, at least two prominent mechanisms of resistance can occur (22). In the first instance, cellular resistance may be attributable to membrane alterations that are reversible, functionally, by treatment with verapamil. In the second, resistance has been postulated to be due to an altered sensitivity of tubulin to the effects of the drugs the primary basis for postulating an altered interaction with tubulin was that a subgroup of cells resistant to vincristine showed enhanced sensitivity to taxol, a drug that can stabilize microtubules. It should be emphasized that differential sensitivities of tubulins from different tumor cells to the effects of vincristine or vinblastine has been proposed as a basis for the susceptibilities of cells to the cytotoxic effects of such drugs (23). Differences have been described in the electrophoretic patterns for tubulins obtained from vin-... 

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