Suberites domuncula

Carotenoid-Protein Complexes. Three new purple-blue carotenoprotein complexes from invertebrate animals have been described. That from the carapace of Orconectes limosus (Amax 335, 460, 675 nm) has astaxanthin (8) and canthaxanthin [p,p-carotene-4,4 -dione (10)] as prosthetic group,30 and that from the fly Rhyn-chosciara americana (Amax 465, 545 nm) has one canthaxanthin and one echinenone [P,P-caroten-4-one (11)] per mole of protein.31 The sponge Suberites domuncula... 

The haemolytic and neurotoxic protein isolated from Suberites domuncula, a silicaceous sponge. Lethal in dogs at 10 mg/kg. Non-toxic by mouth. Effects vomiting, diarrhoea, dyspnoea, haemorrhages into gut, peritoneum and pericardium. 

Le Pennec, G., Perovic, S., Ammar, M.S., Grehenjuk, V.A., Steffen, R., Breummer, F., and Meuller, W.E. 2003. Cultivation of primmorphs from the marine sponge Suberites domuncula Morphogenetic potential of siUcon and iron. J. Biotechnol. 100, 93-108. 

Cariello L, Zanetti L (1981) A blue carotenoprotein from the marine sponge Suberites domuncula purification and properties. Mar Biol 62 151-155... 

Wiens, M., R. Batel, M. Korzhev, and W. E. G. Muller. 2003. Retinoid X Receptor and Retinoic Acid Response in the Marine Sponge Suberites domuncula. J Exp Biol 206, no 18 3261-71. 

Custddio, M.R., Prokic, L, Steffen, R., Koziol, C., Borojevic, R., Briimmer, F., Nickel, M., Muller, W.E.G., 1998. Primmorphs generated from dissociated cells of the sponge Suberites domuncula a model system for studies of cell proliferation and cell death. Mech. Ageing Dev. 105, 45-59. 

Eckert, C., Schroder, H.C., Brandt, D., Perovic-Ottstadt, S., MiiUer, W.E.G., 2006. Ahistochem-ical and electron microscopic analysis of the spiculogenesis in the demosponge Suberites domuncula. J. Histochem. Cytochem. 54, 1031-1040. 

Muller, W.E.G., Rothenberger, M., Boreiko, A., Tremel, W., Reiber, A., Schroder, H.C., 2005. Formation of siliceous spicules in the marine demosponge Suberites domuncula. Cell... 

Thakur, N.L., Hentschel, U., Krasko, A., Pabel, C.T, Anil, A.C., and Muller, W.E.G. (2003) Antibacterial activity of the sponge Suberites domuncula and its primmorphs potential basis for epibacterial chemical defense. Aquat. Microb. Ecol., 31, 77-83. 

The likely bacterial origin of most of these peptides has been confirmed in the case of a series of new cyclic peptides isolated from the culture of a Ruegeria strain (a-proteobacterium) associated with the sponge Suberites domuncula. However, these peptides have only moderate antimicrobial activity (Mitova et al, 2004). 

Mitova, M., Popov, S., and De Rosa, S. (2004) Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.J. Nat. Prod., 67, 1178-1181. 

Schroeder, H., Sudek, S., Caro, S., Rosa, S., Perovic, S Steffen, R., Mueller, I.M., and Mueller, W.E.G. (2002) Synthesis of the neurotoxin quinolinic add in apoptotic tissue from Suberites domuncula cell biological, molecular biological, and chemical analyses. Mar. Biotechnol., 4, 546-558. 

By working with a very small amounts of material Walton and Pennock 182) observed that the sponge Grantia compressa utilized " C-mevalonate for the biosynthesis of isoprenoids (squalene, steroids and ubiquinones) in direct contrast with the complete absence of radioactivity in the terpenoids of Suberites domuncula incubated with C-mevalonate. 

Henze, M. Spongosterin, eine cholestirinartige Substanz aus Suberites domuncula. Hoppe-Seyl. Z. 41, 109 (1904). 

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