Suberites

A saponin-like substance, agelasine, was isolated from Agelas dispar (10). Suber-itine from Suberites domcunculus was originally isolated by Richet (32) and was shown to be heat labile and have a MW of 28,000 by Cariello et al. (33). A cyclic peptide, dolastin, was isolated from Dolabella awicularia (34). 

Suberitine, a small protein from the sponge Suberites domcuncula, has a variety of actions. It is not very toxic but causes hemolysis in human erythrocytes, flaccid paralysis in crabs and depolarization of squid axon and abdominal nerve of crayfish. A variety of extracts from Porifera have been shown to be toxic to fish and generally have cytotoxic and hemolytic actions (62,63). As discussed previously, a variety of sponges exude substances that are toxic to fish. 

Isopr. SESTERTERP. suberitane Suberites sp., Hadromerida, Pwif. frran Antarctica Shin 1995). 

Fig. 3.18 Suberites japonicus, a sponge collected in Zampa, Okinawa, that contains seragamides A-F (1068-1073) (Photo J. Tanaka)...

Tanaka C, Tanaka J, Bolland RF, Marriott G, Higa T (2006) Seragamides A-F, New Actin-Targeting Depsipeptides from the Sponge Suberites japonicus Thiele. Tetrahedron 62 3536... 

Monrad, J.K. Howard, L.R. King, J.W. Srinivas, K. Mauromoustakos, A. 2010b. Suberitical solvent extraetion of proeyanidins from dried red grape pomace. J. Agric. Food Chem. 58 4014-4021. 

Carotenoid-Protein Complexes. Three new purple-blue carotenoprotein complexes from invertebrate animals have been described. That from the carapace of Orconectes limosus (Amax 335, 460, 675 nm) has astaxanthin (8) and canthaxanthin [p,p-carotene-4,4 -dione (10)] as prosthetic group,30 and that from the fly Rhyn-chosciara americana (Amax 465, 545 nm) has one canthaxanthin and one echinenone [P,P-caroten-4-one (11)] per mole of protein.31 The sponge Suberites domuncula... 

The haemolytic and neurotoxic protein isolated from Suberites domuncula, a silicaceous sponge. Lethal in dogs at 10 mg/kg. Non-toxic by mouth. Effects vomiting, diarrhoea, dyspnoea, haemorrhages into gut, peritoneum and pericardium. 

Le Pennec, G., Perovic, S., Ammar, M.S., Grehenjuk, V.A., Steffen, R., Breummer, F., and Meuller, W.E. 2003. Cultivation of primmorphs from the marine sponge Suberites domuncula Morphogenetic potential of siUcon and iron. J. Biotechnol. 100, 93-108. 

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