Subcellular distribution of dopamine receptor labeling in the postsynaptic cell

Subcellular distribution of dopamine receptor labeling in the postsynaptic cell 

Consistent with an extrasynaptic location of dopamine receptors, Huang et al. (1992) found D1 receptor labeling in the heads and the necks of spines, as well as in dendritic shafts at postsynaptic sites apposed to symmetric synapses. Similarly, Levey et al. (1993) found both D1 and D2 receptors localized in spiny dendrites and spine heads. Hersch et al. (1995) used subtype specific polyclonal and monoclonal antibodies to label D1 and D2 subtype receptors. Most prominently labeled were spiny dendrites with intense patches of submembranous label sometimes associated with symmetrical or asymmetrical 

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