Stunning

The classic account of the sinking of the Titanic. A stunning book, incomparably the best on its subject and one of the most exciting books of this or any year - The New York Times... 

Anyway, there have been two very hot topics in chemistry lately clay microwaves. Both have been shown to do remarkable things in preparative organic chemistry. And this article Strike has [58], has combined both to produce some stunning reductive ami-nations of ketones to final amine products. The procedure involves mixing naked ketone, the amine, some clay and some NaBH4 in a beaker and zapping it in the microwave for only a couple of minutes. That s it. The general procedure is as follows ... 

Jptt Kokai Tokkyo Koho JP 02,119,055 (May 7, 1990), M. Teiada, S. Saito, and A. Miuia (to Stun-Kobe Electric Machinery Co. Ltd.). 

In many places, the need for desalination is even more urgent than the production of food, which is limited by water shortages. These shortages exist both in the petroleum-rich countries and in many of the least-developed and poorest countries of the world. In the case of the former, the improved water supply obtained through desalination has already had stunning effects by contrast, Httie hope for progress is on the horizon for the poor countries. 

The crystallographic world was stunned when at a meeting in Erice, Sicily, in 1982, Hartmut Michel of the Max-Planck Institute in Martinsried, Germany, displayed the x-ray diagram shown in Figure 12.12. Not only was this the first x-ray picture to high resolution of a membrane protein, but the crystal was... 

Proteins are the indispensable agents of biological function, and amino acids are the building blocks of proteins. The stunning diversity of the thousands of proteins found in nature arises from the intrinsic properties of only 20 commonly occurring amino acids. These features include (1) the capacity to polymerize, (2) novel acid-base properties, (3) varied structure and chemical functionality in the amino acid side chains, and (4) chirality. This chapter describes each of these properties, laying a foundation for discussions of protein structure (Chapters 5 and 6), enzyme function (Chapters 14-16), and many other subjects in later chapters. 

The bicycle has stunning efficiency advantages over other vehicles for several reasons ... 

With remarkable accuracy, Democritus in the fifth century B.C. set the stage for modem chemistry. His atomic theory of matter, which he formulated without experimental verification, still stands, more or less intact, and encapsulates the profound truth that nature s stunning wealth boils down to atoms and molecules. As science uncovers the mysteries of the world around us, we stand ever more in awe of nature s ingenious molecular designs and biological systems nucleic acids, saccharides, proteins, and secondary metabolites are four classes of wondrous molecules that nature synthesizes with remarkable ease, and uses with admirable precision in the assembly and function of living systems. 

We reflected on this together, the three of us. I admit that the greater part of my reflection was just being stunned. It was like finding out that what you consider your professional role is what others would consider an audition. 

There is exciting new engineering and science in the old field of fuel cells. Even more important, the payoff of this research may be a truly stunning advance in our use of energy. 

A view of the Earth from space shows that our planet is an integrated whole. At the same time, we know that the Earth is mind-boggling in its diversity. Nevertheless, the stunning complexity of our world can be described using a small set of chemical principles. These fundamental aspects of chemistry are the subject of this book. 

Over the eons, the flow and evaporation of water inside a cavern creates a stunning array of rock sculptures. Stalagmites grow upward from the floor, sometimes joining stalactites to form massive columns. Limestone dams create beautiful pools of water. Limestone draperies fall like curtains from water flowing around overhanging rock. Delicate mineral flowers sprout from the walls. All these features result from the aqueous solubility equilibrium of calcium carbonate. 

Figure 4.4 Effect of a free-radical scavenger M-(2-mercaptoproplonyl)-glycine (MPG) on the recovery of contractile function following 15 min of regional ischaemia in the dog heart, (a) MPG infused 1 min before reperfusion, (b) MPG infused 1 min after reperfusion. Contractile function was assessed as changes in ventricular wall thickening measured using an ultrasonic pulsed-Doppler epicardial probe. Note The free radical scavenger MPG can reduce myocardial stunning only when present during the first minute of reperfusion. Redrawn with permission from Bolli et af. (1989).

Przyklenk, K. and Kloner, R.A. (1986). Superoxide dismutase plus catalase improve contractile function in the canine model of the stunned myocardium. Circ. Res. 58, 148-156. 

Bolli, R, Patel, B.S., Jeroudi, M.O., Lai, E.K. and McCay, P.B. (1988). Demonstration of free radical generation in stunned myocardium of intact dogs with the use of the spin trap a-phenyl-N-ferr-butyl nitrone. J. Clin. Invest. 82, 476-485. 

Ascher, E.K. Stauffer, J-C.E. and Gaasch, W.H. Coronary artery spasm, cardiac arrest, transient electrocardiographic Q waves and stunned myocardium in cocaine-associated acute myocardial infarction. 

Given N measurements of the response variables (output vector), the parameters are obtained by minimizing the Linear Least Squares (LS) objective function which is given below as the weighted stun of squares of the residuals, namely,... 

The pro- and anticonvulsant effects of the phencyclinoids were studied by assessing their ability to increase or decrease the intensity of electrically-induced convulsions. A 32 mA, 0.2-second stimulus was delivered via corneal electrodes with a constant-current electroshock apparatus. The shock parameters were chosen to produce a convulsion intensity of "3" on a five-point rating scale as follows 0 = stunned only, 1 = facial and vibrissae tremor, 2 = clonic forepaw treading, 3 = tonic forelimb extension, 4 = tonic forelimb and hindlimb extension, and 5 = death. Thus, both increases and decreases in the convulsion intensity subsequent to drug administration could be observed. 

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