Studying offish

Bums, C. P., Halabi, S., Qamon, G. H., Hars, V., Wagner, B. A., Hohl, R. J., Lester, E., Kirshner, J. J., Vindguerra, V., and Paskett, E., 1999, Phase 1 chnical study offish oil fatty acid capsules for patients with cancer cachexia cancer and leukemia group B study 9473, Clin. CancerRes. 5 3942-3947. 

Although the metabolism of several phthalate esters has been studied in vitro, essentially all of the in vivo studies have involved DEHP. A summary of these experiments which involved exposure offish to aqueous - C-DEHP is presented in Table IV (11,12). Tissue C was isolated and separated into parent and the various metabolites by preparative thin layer chromatography on silica gel. Metabolites were hydrolyzed where appropriate and identified by gas chromatography-mass spectroscopy. In whole catfish, whole fathead minnow and trout muscle, the major metabolite was the monoester while in trout bile the major metabolite was the monoester glucuronide. The fact that in all cases the major metabolite was monoester or monoester glucuronide despite the differences in species, exposure level and duration, etc. represented by these data, suggests that hydrolysis of DEHP to monoester is important in the biotransformation of DEHP by fish. 

Lawrenece River. The results of this study should provide a better understanding of the relative contributions of individual industries to pollution offish and wildlife consumed by area residents. 

Kretser, W., Gallagher, J. and Nicolette, J. (1989). Adirondack Lakes Study. 1984-1987. An evaluation offish communities and water chemistry. Ray Brook (NY) Adirondacks Lakes Survey Corporation. 

The Chinese are studying an extremely toxic substance isolated from a fish to see whether it can ease cancer-related pain and the symptoms of heroin withdrawal. What kind offish ... 

The triglyceride composition offish oils is complex, and detailed studies are not available. Current work on fatty acid distribution suggests that polyunsaturated acids (20 5 n—3 and 22 6 3) occupy... 

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