Studies in Patients with Prolonged Steatorrhea

We were left then with conclusions that one might have anticipated namely, that patients with steatorrhea had a lowered plasma concentration of vitamin E and, as a reflection of this, an increased tendency of their 

The second pathologic finding, ceroid pigment, a product of autoxidation of unsaturated lipids, has been reported in the smooth muscle of the stomach, intestine, bronchial wall, and bladder of children djdng with cystic fibrosis of the pancreas, particularly if they were over 2 years of age (Blanc et al., 1958 Kerner and Goldbloom, 1960). It was less frequent in infants who died with biliary atresia, presumably because of their earlier death. These lesions, which also have been described in adults with the malabsorption syndrome (Pappenheimer and Victor, 1946 Braunstein, 1961) bear a close resemblance to the findings in the vitamin E-deficient animal where the amount of ceroid deposition can be correlated with the level of unsaturated fatty acids in the diet (Mason et al., 1946). 

Using Cr -labeled cells, a shortened erythrocyte life span was found in newborn premature infants (Kaplan and Hsu, 1961). The susceptibility of their erythrocytes to in vitro hemolysis in hydrogen peroxide suggests a possible relationship to their decreased survival in vivo. Indeed, decreased survival has been observed in the vitamin E-deficient monkey (Marvin et al., 1959) although the normal survival in vitamin E-defident rats suggests a species variability (Goldbloom, 1960). The results in humans are inconclusive. A decreased red cell life span was found in adult volunteers on a tocopherol-deficient diet high in polyunsaturated lipids (Horwitt et al., 1961), but survival was normal in a patient with cystic fibrosis of 

Effect op Tocopherol on Cheatinubia and Aminoaciduria of Premature Infants 

Infant Age (days) Period Plasma tocopherol (mg/100 ml) Urinary excretion Amino acid Creatinine Creatine (mg/kg/ (mgAg/  

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