Ceroid pigments

M (increased incidences of clear cell foci, fatty change, and ceroid pigmentation)... 

M (ceroid pigmentation of the adrenal cortex minimal to mild)... 

Lipid peroxidation is increased in vitamin E deficiency, and subsequent catabolism of the peroxides results in the formation of malondialdehyde and other aldehydes. These can form Schiff bases with amino groups of proteins, free amino acids, and nucleic acids. The resultant fluorescent pigments are called ceroid pigments, lipopigments, or lipofuscin, and accumulate in increased amounts in the liver and other tissues of deficient animals (Manwaring andCsallany, 1988). 

Lipofuscin and ceroid pigments. Karger, Basel, Switzerland, p 69... 

Carpenter KLH, van der Veen, C, Taylor SE, Hardwick SJ, Clare K, Hegyi L, Mi tchinson MJ (1995) In Kitani K, Ivy GO, Shimasaki H (eds), Lipofuscin and ceroid pigments. Karger, Basel, Switzerland, p 53... 

The second pathologic finding, ceroid pigment, a product of autoxidation of unsaturated lipids, has been reported in the smooth muscle of the stomach, intestine, bronchial wall, and bladder of children djdng with cystic fibrosis of the pancreas, particularly if they were over 2 years of age (Blanc et al., 1958 Kerner and Goldbloom, 1960). It was less frequent in infants who died with biliary atresia, presumably because of their earlier death. These lesions, which also have been described in adults with the malabsorption syndrome (Pappenheimer and Victor, 1946 Braunstein, 1961) bear a close resemblance to the findings in the vitamin E-deficient animal where the amount of ceroid deposition can be correlated with the level of unsaturated fatty acids in the diet (Mason et al., 1946). 

Some of the patients showed other biochemical, morbid anatomical and clinical evidence of tocopherol deficiency hydrogen peroxide hemolysis, creatinuria, ceroid pigmentation (Pappenheimer and Victor, 1946 Adlers-burg and Schein, 1946 Tuerdy et al., 1949 Blanc et al., 1958 Kerner and Goldbloom, 1960, Froelich et al., 1961) cerebellar lesions (Horwitt and... 

Nevertheless, as a result of these studies and later studies (Gordon el al, 1958), these authors concluded that patients with cystic fibrosis of the pancreas should be given supplements of a-tocopherol. This seems to be a justifiable conclusion. Further studies with early administration of large doses of a-tocopherol may reduce the incidence of muscle necrosis and ceroid pigmentation. 

A type of brownish pigment found in clogged arteries (such as in atherosclerosis), the intestinal lining, and in various types of disorders where polyunsaturated fats are abnormally oxidized. The accumulation of ceroid pigment appears to be associated with deficiencies of selenium and vitamin E. 

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