Structure-switching signalling aptamer

Nutiu, R. Li, Y., In vitro selection of structure-switching signaling aptamers, Angew. Chem. Int. Ed. 2005, 44, 1061-1065... 

Figure 36 The structure-switching signaling aptamer. A DNA duplex composed of three strands of DNA places a fluorophore (F) close to a quencher group (Q). Upon addition of thrombin, the QDNA piece is released, and the fluorescence increases (See ref 67).

Nutiu, R., Li, Y. (2004). Structure-switching signaling aptamers transducing molecular recognition into fluorescence signalling. Chem Eur J 10, 1868-1876. 

Wu, Z-S., Guo, M-M., Zhang, S-B., Chen, C-R., Jiang, J-H., Shen, G-L., Yu, R. Q. (2007). Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling aptamers. Anal Chem 79,... 

Q. (2007). Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling aptamers. Anal Chem 79, 2933-2939. 

Another construction procedure of Fc-labeled structure-switching signaling aptamer as a sohd-state ECL sensing platform for detection of adenosine provided a promising method for aptamer-based small-molecule detection due to its simplicity, rapidity, low cost, and excellent response characteristics [155]. 

FIGURE 16.6 Design of structure-switching signaling aptamers. (Source Copyright (2003), American Chemical Society. With permission.)... 

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