Structure-activity relationships application strategies

One approach to screening subsets of available compounds is to screen sets of compounds that, although not representative of the molecular diversity of the available compound collection, do contain as much structure activity relationship information as possible. An example of this was the Informer Library strategy proposed by CombiChem (which was eventually purchased by DuPont Pharmaceuticals in 1999) (23). Unfortunately, there have been no published applications of this screening strategy that assess its success or failure. 

Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of biaactive natural pfcxjucts and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world s leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies—developed for natural products— with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as cliniciafly useful agents. 

Application Strategies for the Primary Structure-Activity Relationship Exploration... 

APPLICATION STRATEGIES FOR PRIMARY STRUCTURE-ACTIVITY RELATIONSHIP EXPLORATION... 

Application Strategies For Primary Structure—Activity Relationship Exploration 297... 

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