Structural chemistry historical background

Following an introductory section on the historical background that has led to the development of RPC techniques as practiced today, the principles and theory of RPC will be discussed, incorporating the role of amino acid sequence and hierarchical structural effects that determine the outcome of the interaction of a peptide(s) with various types of nonpolar chromatographic surfaces. Subsequently, the influence of operating parameters such as the effects of different (1) surface morphologies or chemistries of nonpolar sorbents (2) concentrations of organic solvents, salts, or other mobile-phase additives (3) pH conditions or... 

For accounts of the resistance to atomism and the rise of structural chemistry, see Brock (1967, 1992) and Knight (1992). Mason (1976) provides a historical survey of stereochemistry. Some biographical background to Pasteur s researches can be found in Jacques (1993). 

Since the appearance of computer-aided structure-activity studies, the term pharmacophore has become one of the most popular words in medicinal chemistry. However, depending on their scientific background and/or traditions, the different medicinal chemistry groups attribute various meanings to this term. Therefore, it appeared necessary to devote a brief paragraph to the definition of the word pharmacophore, and this is followed by a historical perspective and finally by some comments from a medicinal chemistry practitioner. 

The first actinide organometallic complex, red-brown (C5H5)3UC1, was prepared and characterized by Reynolds and Wilkinson in 1956 or shortly after the discovery of ferrocene see Ferrocene, (C5H5)2pe. However, it was not until the preparation and structural characterization of bis(cyclooctatetraenyl)uranium, (C8H8)2U ( uranocene , see Uranocene) in 1968 and the isolation and characterization of uranium alkyls see Alkyl Complexes) in 1973 that the field developed momentum. The purpose of this chapter is to provide an overview of organoactinide chemistry that reflects historical as well as recent developments and achievements in the field it is not meant to be an exhaustive review of the primary literature. More detailed discussion, background material, and extensive references to the literature can be found in several excellent reviews. 

---