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Stressful levels, cell response transcriptional, processes

In primary cultures of neonatal cerebellar granule neurons, all Ca2+ sensors, calmodulin, protein kinases C (PKC), and the p21(ras)/phosphatidylinositol 3 -kinase (Ptdlns-3K)/Akt pathway, converge towards NF-kB at the levels of nuclear translocation as well as transcription. The duration of NF-kB activation is a critical determinant for sensitivity toward excitotoxic stress and is dependent on the different upstream and downstream signaling associated with various kinases. This is in contrast to studies in non-neuronal cells, which either do not respond to Ca2+ or do not simultaneously activate all three cascades (Lilienbaum and Israel, 2003). Collective evidence suggests that brain inflammatory processes differ from systemic inflammation not only in the involvement of various types of neural cells but also in differences in response to second messengers. [Pg.141]


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See also in sourсe #XX -- [ Pg.80 ]




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Cell processes

Cell stress

Process response

Processing cell

Processing stresses

Response cells

Stress transcriptional, processes

Stressful levels, cell response

Transcription process

Transcription processing

Transcription transcript processing

Transcriptional responses

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