Stress response signaling

Hu, M. C., Wang, Y, Qiu, W. R., Mikhail, A., Meyer, C. E, and Tan, T. H. (1999). Hematopoietic progenitor kinase-1 (HPKl) stress response signaling pathway activates IkappaB kinases (IKK-alpha/ beta) and IKK-beta is a developmentally regulated protein kinase. Oncogene 18(40), 5514-5524. 

Eukaryotic Stress Response Signaling Pathways as Mechanistic Targets for Functional Foods... 

EUKARYOTIC STRESS RESPONSE SIGNALING PATTfl/UAYS... 

G proteins are molecular amplifiers for a large number of seven-trans-membrane helix receptors that regulate responses like vision, smell and stress response. They are heterotrimeric molecules, Gap, that dissociate into membrane-bound Ga and Gpy signal transmitters upon activation of the receptor. 

A cell subjected to a stress of any kind can potentially exhibit a wide range of responses. Severe stress may lead to cell death and, ultimately, to cell lysis imposition of less severe conditions may result in a metabolically perturbed system, which may either revert to its initial state or adapt in some way to the imposed conditions. Figure 10 shows a hypothetical scheme, presented by Prokop and Bajpai [12], for the signal-response cascade associated with hydrodynamic shear stress. The signal reception/transduction mechanisms are, as yet, poorly understood. While Fig. 10 can be applied to any biological system, Namdev and... 

Cortisol is an important component of the body s response to physical and psychological stress. Nervous signals regarding stress are transmitted to the hypothalamus and the release of CRH is stimulated. The resulting increase in cortisol increases levels of glucose, free fatty acids, and amino acids in the blood, providing the metabolic fuels that enable the individual to cope with the stress. A potent inhibitor of this system is cortisol itself. This hormone exerts a negative-feedback effect on the hypothalamus and the adenohypophysis and inhibits the secretion of CRH and ACTH, respectively. 

Signal transduction (control of cellular stress responses and MAP-kinase pathways)... 

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