Stress contractile

Relatively selective stimulation of Pi-adrenergic receptors can be achieved with dobutamine. This is a racemic drug of which both isomers activate the Pi-receptor, and in addition the (-) isomer activates ( -receptors whereas the (+) isomer activates p2-receptors the simultaneous activation of ai- and p2-receptors results in no major net effect on peripheral resistance, and thus the overall cardiovascular effects are mediated by Pi-stimulation leading to increases in cardiac contractility and output. Dobutamine is used for the short-term treatment of acute cardiac failure and for diagnostic purposes in stress echocardiography. 

It is most unlikely that the sole functions of mysoin-Il in nonmuscle cells are to provide the contractile force to bisect cells during cytokinesis and for the contractility of stress fibers. Myosin-II is present in a variety of cell types at moderate concentrations in tissues such as brain, which are almost totally non-mitotic and do... 

In order to proceed with the evaluation of the time-dependent Poisson ratio v(0, both sets of relaxation behaviour are required. Now from Chapter 2 we know the Poisson ratio is the ratio of the contractile to the tensile strain and that for an incompressible fluid the Poisson ratio v = 0.5. Suppose we were able to apply a step deformation as we did for a shear stress relaxation experiment. The derivation then follows the same course as that to Equation (4.69) ... 

Skeletal muscle glycogen delivers glucose primarily as a response to contractile stress. Regulation occurs through both modification of the enzyme phosphorylase, primarily by the action of epinephrine-adrenaline and allosteric regulation of phosphorylase related to a demand for ATP. 

Dual isotope SPECT protocols obtain resting images with t1 and stress images with MIBI followed by 24 h xi late redistribution imaging [39, 40]. These protocols have demonstrated good prediction of contractile function recovery after revascularization comparable to simpler single tracer protocols [41]. 

Knock-out Impaired cardiac contractility in response to (3-adrenergic stimulation and hemodynamic stress Reduced anxiety-related responses and increased exploratory drive in male KO mice Prolonged Q-T intervals, reduced Ca2+-induced Ca2+ release upon 3-adrenergic stimulation. 

Du XJ, Cole TJ, Tenis N, Gao XM, Kontgen F, Kemp BE, Heierhorst J. 2002. Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol 22(8) 2821-2829. 

In addition to its effects on cardiac contractility, digitalis has a direct inhibitory effect on sympathetic nervous system activity.37,60 This effect is beneficial because it decreases stress on the failing heart by decreasing excessive sympathetic stimulation of the heart and peripheral vasculature2. Therapeutic levels of digitalis likewise stabilize heart rate and slow impulse conduc-... 

Serneri, G.G.N., Modesti, PA., Boddi, M., Cecioni, I., Paniccia, R., Coppo, M., Simonetti, I., Vanni, S., Papa, L., Bandinelli, B., Migliorini, A., Modesti, A., Maccherini, M., Sani, G., and Toscano, M. 1999. Cardiac growth factors in human hypertrophy relations with myocardial contractility and wall stress. Circ. Res. 85 57-67. 

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