Streptomycin drug interactions

Another point that has defied explanation is this SM is bacteriocidal only during periods of high rates of protein synthesis. Thus other protein inhibitors such as tetracyclines or chloramphenicol should interfere with its action, yet this theoretical drug interaction is not necessarily clinically contraindicated. In fact, a combination of streptomycin and tetracycline is the treatment of choice for glanders and brucellosis. 

Certain aminoglycoside antibiotics, including gentamicin and streptomycin, have been observed to interact with the acidic mucopolysaccharide heparin, condroitin sulfate, and hylauronic acid with reduction of antibacterial activity. The interaction of aminoglycosides with the acidic mucopolysaccharides has been suggested to result in the accumulation of the drug in the kidney and in the inner ear and to partly account for the well-documented nephrotoxicity and ototoxicity of this group of antibiotics. 

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