Streptomycin dependence

Mutagenic activity. Ethanol (95%) extract of the dried resin, on agar plate at a concentration of 15 mg/plate, produced weak activity on streptomycin-dependent strains of Salmonella typhimurium TA98. Metabolic activation has no effect on the result " """. Resin, on agar plate at a concentration of 200 pg/plate, was active on Salmonella typhimurium TA1537 and inactive on Salmonella typhimurium TA1538 and Salmonella typhimurium TA98 " """. 

Desai, H. G., and R. H. Kalro. Effect of black pepper asafetida on the DNA content of gastric aspirates. Indian J Med Res 1985 81 325-329. Shashikanth, K. N., and A. Hosono. In vitro mutagenicity of tropical spices to streptomycin dependent strains of Salmonella typhimurium TA98. Agr Biol Chem 1986 50(11) 2947-2948. Kamboj, V. P. A review of Indian medicinal plants with interceptive activity. Indian J Med Res 1988 1988(4) 336-355. 

Bilgin N, Ehrenberg M (1994) Mutations in 23S ribosomal RNA perturb transfer RNA selection and can lead to streptomycin dependence. J Mol Biol 235 813-824... 

V. Damjanovic, Kinetics of thermal death and prediction of the stabilities of freeze-dried streptomycin-dependent live Shigella vaccines. J. Biol. Stand. 2 297-311, 1974. 

R25. Rosenkranz, H. 8., Unusual alkaline phosphatase level in streptomycin-dependent strains of E. Coli. Biochemistry 2, 122-125 (1963). 

Shashikanth, K.N., and A. Hosono. 1987. Screening of streptomycin-dependent strains of Salmonella typhimurium and Escherichia coli for in vitro detection of spice-induced mutagenicity. Lebensmittel-Wissenschaft Technol. 20(2) 91-94. 

A dried ethanolic extract of anise exhibited mutagenic activity at high concentrations (5 mg/plate) in a streptomycin-dependent strain of Salmonella typhimurium TA98 (Shashkanth and Hosono 1986). 

Use of a dominant rpsL allele conferring streptomycin dependence for positive and negative selection in Thermus thermophUus. Appl. Microbiol Biotechnol, 73, 5138-5145. 

Gregory, S.T., Cate, J.H.D., and Dahlberg, A.E. (2001) Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophUus. J. Mol Biol, 309, 333-338. 

Resistance to and dependence on streptomycin occur in a single gene and mutations to streptomycin dependence and its revertant are closely... 

Nutritional dependence on pterinoid antimetabolites is a fascinating phenomenon and part of the problem of resistance to the antifolics in cancer therapy. Law (1958) noted that some strains of mouse leukemia have become dependent on antifolics. Is the explanation like that for Neurospora If one had antifolio-dependent strains of protozoa and bacteria, analysis of their growth requirements might uncover new metabolites, as happened for streptomycin-dependent bacteria. 

Banerjee, A. B., and S. K. Bose Biosynthesis of mycobacillin, a new antifungal peptide. II. Relation between streptomycin dependence and biosynthesis. J. Bacteriol. 87, 1402 (1964 b). 

Streptomycin-dependent bacteria do not owe this genetically-based oddity to contact with the drug, but have an inbuilt metabolic error that the drug corrects (Goldstein, 1954 Mitchison, 1962). 

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