Streptomyces tendae

Dionigi, C.P. et al.. Spore and geosmin production by Streptomyces tendae on several media, J. Agric. Food Chem., 40, 122, 1992. 

Fig. 2. Cross-section of the pellet (0 = 2 mm, left) and filaments (right) of Streptomyces tendae.

Vecht-Lifshitz SE, Magdassi S, Braun S, Effect of addition of surface active agents on pellet formation in submerged fermentation of Streptomyces tendae, JDisp Sci... 

Figure 2. Geosmin production and fresh biomass accumulation by Streptomyces tendae cultures on Hickey Tresner and Actinomyces Media. Data are expressed 2 SE of a mean (Adapted from ref. 43).

Figure 3. Effects of famesol on fresh matter accumulation by Streptomyces tendae cultures grown on either Hickey-Tresner (HT) or Actinomyces (ACT) medium. Data are expressed 1 SE of the mean (Adapted from ref. 42),...

Streptomyces tendae Escherichia coli 1 carboxyl-terminal domain Human Homo sapiens)... 

Nikkomycins Z 94 and X 95, isolated as nucleoside antibiotics from Streptomyces tendae 221 inhibit chitin biosynthesis and have fungicidal and insecticidal properties. 

In addition, nikkomycin B 96 223which has a p-hydroxyphenyl residue in the N-terminal amino acid instead of the 3-hydroxypyridine system of 95, was isolated from the culture filtrate of Streptomyces tendae. 

Nikkomycins are nucleoside amide antibiotics produced by Streptomyces tendae Tii 901 and are known to show antifungal, anti-insecticidal, and acaricidal activities. They are competitive inhibitors of chitin synthase. Nikkomycins are produced as a complex mixture, with nikkomycin Z (13) and nikkomycin X (14) representing the major components. ... 

Histidine ammonia lyase (HAL, histidinase, histidine-a-deaminase, E.C. 4.3.1.3) is capable of abstracting ammonia from L-histidine (17), resulting in the formation of urocanoic acid [Scheme 12.6-4, (6)], an intermediate in the metabolism of l-histidine,n). HAL has also been identified as a key enzyme in the synthesis of secondary metabolites such as Nikkomycin in Streptomyces tendae,ul The mechanism of the enzyme has been investigated and seems to proceed via the carbanion intermediate111, 13]. Synthetic applications of HAL are difficult to achieve, particularly as the enzyme is sensitive to oxygen1131. The utility of HAL is limited to niche applications such as the synthesis of radiolabeled urocanic acids as tracers of histidine metabolism1"1. 

Fiedler, H. P., Kulik, A., and Schuz, T C. (1994) Biosynthetic capacities of Actinomycetes. 2. Juglomycm Z, a new naphthoquinone antibiotic from Streptomyces tendae. J. Antibiot. 47,1116-1122... 

The a-amylase inhibitor tendamistat (Hoe 467A, C345H523N9JO,, 984, Mr 7957.77) is isolated from Streptomyces tendae. This polypeptide has potent antidiabetic activity. 

A group of aminoacylamino- nucleoside antibiotics (more than 25 components) from cultures of Streptomyces tendae, see also polyoxins. The N. exhibit acar-icidal, insecticidal, and antifungal activities. The activity is based on an inhibition of chitin biosynthesis as a result of the structural analogy to UDP-Al-acetyl-... 

Nikkomycins are a group of peptidyl nucleoside antibiotics produced by Streptomyces tendae Tii901 [318] and Streptomyces ansochromogenes 7100 [319]. Since their structure is similar to that of the chitin synthase substrate... 

Naphthoquinone antibiotic. Prod, by Streptomyces tendae. Active against gram-positive and -negative bacteria and yeasts. Mp > 300°. [a] +144 (c, 0.02 in MeOH). 

Hayashi and co-workers used a similar strategy (Scheme 25) for the formal total synthesis of nikkomycin B (107) (96), a nucleoside peptide antibiotic isolated from the culture broth of Streptomyces tendae. In the key step, propionaldehyde (60), furfural (108), and the TBS-protected aniline 109 were reacted in the presence of... 

Nikkomycin Insecticidal CYP162A1 (NikQ) Streptomyces tendae Histidine p-hydroxylation to form nik-komycins X and I [159, 799]... 

Bruntner C, Lauer B, Schwarz W, Mohrle V, Bor-mann C (1999) Molecular characterization of cotranscribed genes from Streptomyces tendae Tu901 involved in the biosynthesis of the peptidyl moiety of the peptidyl nucleoside antibiotic nikkomycin. Mol Gen Genet 262 102-114... 

Nucleoside antibiotic. Isol. from Streptomyces tendae. Antifungal and insecticide. Powder. 

Nucleoside antibiotic. Isol. from Streptomyces tendae. Active against insects and fungi. Solid. Sol. H2O, Py poorly sol. butanol, hexane. 287 (e 16500) (HCl) (Berdy). 307 (e 12800) (NaOH) (Berdy). 

Deoxy Nikkomycin Lz C20H25N5O9 479.446 Prod, by a genetically engineered Streptomyces tendae. Antifungal agent. 

Nucleoside antibiotic. From Streptomyces tendae. Exhibits lower activity than other Nikkomycins. 

Nucleoside-type antibiotic. Metab. of Streptomyces tendae and from Streptomyces cacaoi. Antifungal agent which also inhibits chitin biosynth. 

V6rtesy, L., Oeding, V., Bender, R., 2Jepf, K. and Nesemann, G. (1984) Tendamistat (HOE 467), a tight-binding a-amylase inhibitor from Streptomyces tendae 4158, Eur. J. Biochem., 141, 505-512. 

Aromatic hydroxylation also belongs to the common P450 reactions. P450NikF from Streptomyces tendae Tii901 has been claimed to catalyze hydroxylation of pyridylhomothreonine (14) to form hydroxypyridylhomothreonine (15) in the biosynthesis of nikkomydn, an inhibitor of diitin synthase [61] (Scheme 12.4). Many P450s have been engineered toward aromatic hydroxylation, since this ability makes them attractive candidates for the production of fine chemicals (see Sections 12.4 and 12.5.3). 

Vecht-Lifshitz, S. E., S. Magdassi, and S. Braun (1990). PeUet formation and cellular aggregation in Streptomyces tendae, Biotechnol. Bioeng., 35, 890-896. 

Streptomyces tendae produces an extracellular hydrophobic peptide referred to as streptofactin (Richter et al. 1998). Streptofactin is a mixture of structurally related peptides ranging in molecular mass from 1,003 to 1,127 Da. Streptofactin reduced the surface tension of water from 72 mN/m to 39.4 mN/m and had a critical micelle concentration of 36 mg/1. Interestingly, streptofactin restored the ability of mutants defective in aerial mycelium formation to develop normally. It was suggested that streptofactin plays a role in Streptomyces development by allowing for the erection of aerial hyphae by lowering the surface tension of water films enclosing the colonies. 

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