Streptomyces filipinensis

Rochet and Lancelin50 reported revised 1H and 13C NMR assignments of the polyene antibiotic Filipin m (83). This macrolide which was isolated from Streptomyces filipinensis was reinvestigated in DMSO-dg solution using homonuclear and heteronuclear correlation spectroscopy. In addition to several corrections to previous 1H NMR... 

Streptomyces sp. Colletotrichum gloeosporioides Streptomyces sp. Streptomyces sp. Micromonospora echinospora Streptomyces hygroscopicus Streptomyces filipinensis Streptomyces antibioticus... 

Heneicomycin (88) had previously been isolated from Streptomyces filipinensis[261 ]. Its structure has now been reported, having been determined using UV, MS, HRMS, and one- and two-dimensional lH and 13c NMR [262]. 

C26H35N5O12S, Mr 641.65, yellow powder, [a]D-13.2 (HjO). A topoisomerase II (DNAgyrase) inhibitor from cultures of Streptomyces filipinensis. C. is a novel antibacterial lead structure. Significant improvement of activity has been found with the analogue RO-61-6653 of seco-cyclothialidine. 

Biphenomycin B 11 is a 15-membered cyclic tripeptide isolated from the culture broths of Streptomyces filipinensis and S. griseorubuginosus. This compound displayed potent activity against Gram-positive, p-lactam-resistant bacteria, such as Streptococcus aureus. Enterococcus faecalis, or Streptococcus sp. The enantioselective total syntheses of biphenomycin B 11 using an asymmetric phase-transfer alkylation were reported by two groups. 

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