Streptomyces bikiniensis

S. L. Ward, Z. Hu, A. Schirmer, R. Reid, W. P. Revill, C. D. Reeves, O. V. Petrakovsky, S. D. Dong, and L. Katz, Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae, Antimicrob. Agents Chemother., 48 (2004) 4703-4712 and references therein. 

A close relationship between eporulation and secondary biosynthesis by Streptomyces kanamyceticus (14) and in Streptomyces bikiniensis was described (l5). Non-sporu-lating variants were obtained with acriflavine treatment which lost the ability to produce the antibiotics. If it is assumed that the structural genes of the biosynthetic pathway are localized in chromosome, the deletion of ex-trachromosomal DNA may cause a loss of the ability to produce an endogenous inducer. Induction of the enzymes governing the formation of secondary metabolites would thus be closely associated with the expression of other traits, particularly sporulation. This fact was observed by Drew et al. (16) induction of cephalosporin C formation in Cephalosporium acremonium by methionine was ac-companied by arthrospore formation. 

Chalcomycin ChmHl Streptomyces bikiniensis C20 methyl macrolide hydroxylation [308]... 

Streptomycin Streptomyces bikiniensis Entrapment in calcium alginate beads [63]... 

Jetty, A., Rao, A.G, Rao, B.S., Madhavi, G. et al. (2005) Comparative studies of air lift and fluidized bed reactors for streptomycin production by iimnobi-lized cells of Streptomyces bikiniensis... 

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