Streptococcus haemolyticus

Co-enzyme obtained from cultures of various strains of Streptococcus haemolyticus and capable of changing plasminogen into plasmin (complex enzyme mixture of streptokinase, streptodornase and streptolysin 0"). From fermentation liquors of hemolytic streptococci species Streptococcus haemolyticus), e. g. H 46 A. 

Streptokinase is a 48 kDa extracellular bacterial protein produced by several strains of Streptococcus haemolyticus group C. Its ability to induce lysis of blood clots was first demonstrated in 1933. Early therapeutic preparations administered to patients often caused immunological and other complications, usually prompted by impurities present in these products. Chromatographic purification (particularly using gel filtration and ion-exchange columns) overcame many of these initial difficulties. Modern chromatographically pure streptokinase preparations are usually supplied in freeze-dried form. These preparations (still obtained by non-recombinant means) often contain albumin as an excipient. The albumin prevents flocculation of the active ingredient upon its reconstitution. 

The dimaleate salt of 5,5-dimethyl-10-(4-methylpiperazino)-10,ll-dihydro-5H-dibenzo[b,/]silepin (45c) exhibited some antibacterial activity in vitro toward Mycobacterium tuberculosis H37Rv (minimum inhibitory concentration 12,5/igml ), Streptococcus -haemolyticus (25/igml ) and Staphylococcus pyogenes aureus (25/igml ) (76CCCC910). 

Brisson-Noel, A., and Courvalin, P. (1986). Nucleotide sequence of gene linA encoding resistance to lincosamide in Streptococcus haemolyticus. Gene 43, 247-253. 

Showdomydn 2-P-D-ribofuranosylmaleinimide, a C-substituted Nucleoside antibiotic (see) from Strep-tomyces showdoensis, structurally relat to uridine and pseudouridine. M.p. 153 °C, [aj + 50° (c = 1, water). It selectively inhibits enzymes of uridine and orotic acid metabolism the maleinimide moiety reacts with sulfhydryl groups of the affected enzymes. S. is especially active against Streptococcus haemolyticus. 

Glycoprotein consisting of subunits each of MW approx. 5000. Isol. from Streptococcus haemolyticus. Shows antitumour activity. Sol. H2O. 

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