Stratosphere Plugs

Fig. 7.10 Polymer-supported scavengers polystyrene-bound diamine (top left), silica-based diamine (top right), Stratosphere Plugs (bottom left), and Synphase Lanterns (bottom right).

In principle any pre-functionalized resin can be formed into a plug and the monoliths show good solvent resistance except to e.g. hot toluene or xylene. The size of each plug makes them easily manipulated by a robot and use in scavenging situations seems very attractive. Some applicahons have already been reported [56] and the monoliths will be made available as StratoSphere Plugs via Polymer Laboratories (Church Stretton, UK). 

Combinatorial chemistry has moved from specially centralized laboratories, often equipped with multimillion-dollar robots, onto the bench of individual medicinal chemists. This change in direction requires the availability of personal chemistry tools that are simple to operate, easy to arrange in the laboratory, and reasonably priced. Such instruments are now available for the effective synthesis of combinatorial libraries. The Encore synthesizer represents a simple and efficient personal chemistry tool that allows the execution of directed split-and-pool combinatorial synthesis. The current version of the Encore synthesizer is designed for solid-phase synthesis on SynPhase Lanterns however, it can be modified for synthesis on alternative solid supports such as resin plugs from Polymer Laboratories (e.g., StratoSpheres Plugs). 

Scheme 8.50 Kinetic evaluation of polystyrene and silica supported diamines with SynPhase Lanterns and StratoSphere plugs.

Gasoline and oxygen coexist quietly until a spark from a spark plug propels them into violent reaction. Why Why are ozone molecules in the stratosphere destroyed more rapidly in the presence of chlorine atoms released from CFG molecules In order to understand these situations, we need to take a look at a model called collision theory, which is useful for visualizing the process of chemical change. 

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