Store-operated Ca2+ Entry

An ER protein (though perhaps also expressed elsewhere) that senses the Ca2+ content of the ER and thereby regulates store-operated Ca2+ entry. 

Stimulant Dtugs Store-operated Ca2+ Entry Streptokinase Stress... 

GEA3162 can activate non-store-operated Ca2+ entry, but can inhibit store-operated Ca2+ entry pathways in rat neutrophils [71]. The dual effects of GEA3162 on the regulation of the external Ca2+ entry are mainly through the thiol modification of target protein(s) residing on the outside of the plasma membrane [72],... 

Chetham PM, Babal P, Bridges J, Moore T, Stevens T. Segmental regulation of pulmonary vascular permeability by store operated Ca2+ entry. Am J Physiol 1999 276 L41. 

G. Rocchitta, R. Migheli, M.P. Mura, G. Esposito, M.S. Desole, E. Miele, M. Miele, and P.A. Serra, Signalling pathways in the nitric oxide donor-induced dopamine release in the striatum of freely moving rats evidence that exogenous nitric oxide promotes Ca2+ entry through store-operated channels. Brain Res. 1023, 243-252 (2004). 

Channels associated with capacitative calcium ion entry have been characterized electrophysiologically. In leukocytes, the current associated with the depletion of intracellular Ca2+ stores is highly Ca2+-selective and, on the basis of noise analysis, is believed to involve minute single channels [16] (see Ch. 6). This is the calcium release-activated calcium current (ICrac)- In other cell types, currents with significantly different properties have been identified, including in some instances store-operated nonse-lective cation channels. These marked electrophysiological distinctions may be indicative of distinct channel types mediating capacitative calcium ion entry in different cell types. 

Kiselyov K, Mignery GA, Zhu MX, Muallem S 1999 The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol Cell 4 423-429 Lee HC 2000 NAADP An emerging calcium signaling molecule. J Membr Biol 173 1 -8 Lin S, Fagan KA, Li K-X, Shaul PW, Cooper DMF, Rodman DM 2000 Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry. J Biol Chem 275 17979-17985... 

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