Stewart-Jones

Bryan PC, Efiong DO, Stewart-Jones J, Turner P. Propranolol on tests of visual function and central nervous activity. Br J Clin Pharmacol 1974 1 82. 

G. B. E. Stewart-Jones et al., A structural basis for immunodominant human T cell receptor recognition, Nature Immunology, 4, 2003, 657-63. 

Stein, O.R., Borden-Stewart, D.J., Hook, P.B., and Jones, W.L., Seasonal influence on sulfate reduction and zinc sequestration in subsurface treatment wetlands, Water Research, 41 (15), 3440-3448, 2007. 

Few data were available that met the definitions of AEGL end points. One inhalation study with 20 human subjects described headaches and slight loss of balance at exposure concentrations of 0.1 to 1.5 ppm for exposure durations of up to 8 h (Stewart et al. 1974). Acute exposure of monkeys for 6 h at concentrations ranging between 70 and 100 ppm resulted in severe signs of toxicity including convulsions but no deaths (Jones et al. 1972). In the same study, exposure of rats at a higher concentration, 189 ppm for 4 h, resulted in no toxic signs. Examination of the relationship between exposure duration and concentration for both mild and severe headaches in humans over periods of 1 to 8 h determined that the relationship is C xt=k. 

The exposure levels leading to renal damage in humans have not been well defined. An increased incidence of proteinuria was reported in workers exposed to vapor concentrations of around 200 ppm (Barnes and Jones 1967), while no change was observed in urinary properties following inhalation exposure to 50 ppm for 70 minutes or 10 ppm for 3 hours (Stewart et al. 1961). 

Paustenbach et al. 1986 Sakata et al. 1987). While human studies have suggested hepatic acute LOAELs of 50-200 ppm and NOAELs of 10-80 ppm (Barnes and Jones 1967 Heimann and Ford 1941 Stewart et al. 1961), they each have deficiencies that preclude their use as a basis for MRL derivation. 

Carboxylic acids, esters, and amides are shown in this table to be protonated on the carbonyl oxygen. There has been some controversy on this point, but the weight of evidence is in that direction. See, for example, Katritzky Jones Chem. Ind. (London) 1961, 722 Ottenheym van Raayen Smidt Groenewege Veerkamp Reel. Trav. Chim. Pays-Bas 1961, SO, 1211 Stewart Muenster Con. J. Chem. 1961,39, 401 Smith Yates Can. J. Chem. 1972, 50. 771 Benedetti Di Blasio Baine J. Chem. Soc. Perkin Trans. 2 1980, 500 Ref. 8 Homer Johnson, in Zabicky The Chemistry of Amides Wiley New York, 1970, pp. 188-197. It has been shown that some amides protonatc at nitrogen see Perrin Acc. Chem. Res. 1989, 22, 268-275. For a review of alternative proton sites, see Liler Adv. Phys. Org. Chem. 1975, II, 267-392. 

Fatalities have been associated with acute or prolonged exposure to dichloromethane (Moskowitz Shapiro, 1952 Ku elova et al., 1975 Stewart Hake, 1976 Bonventre etal., 1977 Bakinson Jones, 1985 Manno etal., 1989). Temporary neurobehavioural effects have been reported after exposure to doses as low as 200 ppm [694 mg/m ] by some (Winnekke, 1974 Putz et al., 1976) but not by others (Gamberale et al., 1975). 

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