Stevens-Johnson syndrome management

Cheriyan S, Patterson R. Recurrent Stevens-Johnson syndrome secondary to Herpes simplex, a follow up on a successful management program. Allergy Asthma Proc 1996 17(2) 71-3. 

Pushker N, Tandon R, Vajpayee RB. Stevens-Johnson syndrome in India — risk factors, ocular manifestations and management. Ophthahnologica 2000 214(4) 285-8. 

Drug overdose Of 16 796 toxic exposures to antiepileptic drugs (phenytoin, valproic acid, and carbamazepine) in the USA in 2006, 12 resulted in death, as reported by the US Toxic Surveillance System [67 ]. Some specific problems determined by overdose of some old and new antiepileptic drugs have been briefly reviewed. For example, topiramate can cause a significant metabolic acidosis, lamotrigine Stevens-Johnson syndrome, oxcarbazepine hyponatremia, and levetiracetam psychosis. Possible adoption of guidelines for critical care management of overdose are discussed. 

Skin Allopurinol has commonly been implicated in Stevens—Johnson syndrome and toxic epidermal necrolysis [85 ]. This association has been confirmed by an analysis from Singapore. Of 85 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis managed in Singapore from 2003 to 2007, allopurinol was implicated in 13 cases [86 ]. The HLA-B 5801 allele is associated with severe cutaneous adverse reactions caused by allopurinol in the Han Chinese population [87 ]. The association between allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis and HLA-B 5801 has also been confirmed in Thai and Japanese patients [88 89. ... 

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