Toxic epidermal necrolysis management

Skin Allopurinol has commonly been implicated in Stevens—Johnson syndrome and toxic epidermal necrolysis [85 ]. This association has been confirmed by an analysis from Singapore. Of 85 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis managed in Singapore from 2003 to 2007, allopurinol was implicated in 13 cases [86 ]. The HLA-B 5801 allele is associated with severe cutaneous adverse reactions caused by allopurinol in the Han Chinese population [87 ]. The association between allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis and HLA-B 5801 has also been confirmed in Thai and Japanese patients [88 89. ... [Pg.250]

Chave, T.A. et al., Toxic epidermal necrolysis current evidence, practical management and future directions, Brit. J. Dermatol., 153, 241, 2005. [Pg.631]

Eisen ER, Fish J, Shear NH. Management of drug-induced toxic epidermal necrolysis. J Cutan Med Surg 2000 4(2) 96-102. [Pg.2819]

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