Steroids similarity matrices

The current version of this approach uses N x N matrices (N being the number of molecules included in the data set), in which the 3D similarity indices of each molecule as compared to every other molecule of the whole set are the non-diagonal elements of the similarity matrix [1064, 1065]. In an application to the affinities of 31 steroids to corticosteroid- and testosterone-binding globulins (same data as used in CoMFA studies, e.g. [36]), Carbo index similarity matrices were calculated for the shape and the electrostatic potentials of all molecules. Using the similarity... 

Immunoassays are subject to some effects and interferences unique to immunoassay and some common to all chemical assays (Wu 2000). Establishment of an assay should include some assessment of antibody interference, signal interference, and matrix and hook effects. Interference may be caused by cross-reactivity or by an endogenous metabolite (e.g., in steroid hormone immunoassays) or a xenobi-otic (or metabolite) with a similar structure this problem occurs more frequently... 

Yamamoto et al. (69) have described the combination of TLC with secondary ion mass spectrometry for the determination of acetylcamitine and propionylcamitine in urine. Quantitation was accomplished with a stable isotope dilution method. Kajiura (70) described a TLC/SIMS application to the determination of phospholipid and steroid mixtures, with chromogenic reagents for spot visualization and either triethanolamine or glycerol as the extraction/ionization matrix. A similar application to phospholipids was described the same year by Hayashi et al. (71). Phospholipids as... 

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