Steroidogenic acute regulatory protein STAR

CBP is predicted by PSORT analysis to be a cytoplasmic protein (Horton et al. 2007) and to contain a steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain of 200 amino acids at its C-terminus (Figure 24.2a). 

Miller, W. L. 2007. Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta, 1771(6) 663-676. 

Tuckey RC, Headlam MJ, Bose HS, Miller WL Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR). f Biol Chem 277 47123-47128,2002. 

The initial rate limiting step in the transport of intracellular cholesterol to sites of steroidogenesis is mediated by a steroidogenic acute regulatory protein (StAR) that is regulated by adrenocorticotropic hormone (ACTH). 

Choi, Y. S., Stocco, D. M., and Freeman, D. A. (1995). Dieillyluinbelliferyl phosphate inhibits stcroidogene.si.s by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR). Eur. J. Biochem. 234, 680-685. 

Arakane E, King SR, Du Y, Kallen CB, Walsh LP, Watari H., Stocco DM, Strauss JF III (1997) Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J Biol Chem 272 32656-32662... 

DHT Dihydrotestosterone StAR Steroidogenic acute regulatory (protein)... 

StAR protein Steroidogenic acute regulatory protein... 

Bauer, M.P., J.T. Bridgham, D.M. Langenau, A.L. Johnson and F.W. Goetz. Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Mol. Cell. Endocrinol. 168 119-125, 2000. 

Walsh, L.P., C. McCormick, C. Martin and D.M. Stocco. Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ. Health Perspect. 108 769-776, 2000. 

One well-established component of the intracellular cholesterol-transport system Is the steroidogenic acute regulatory (StAR) protein. This protein, which is encoded in nuclear DNA, controls the transfer of cholesterol from the cholesterol-rich outer mitochondrial membrane to the cholesterol-poor Inner membrane, where it undergoes the first steps in its enzymatic conversion into steroid hormones. StAR-mediated cholesterol transport Is a key regulated, ratecontrolling step in steroid hormone synthesis. StAR contains... 

Reinhart, A. J., Williams, S. C., Clark, B. J., and Stocco, D. M. (1999). SF-1 (steroidogenic factor-1) and C/EBP beta (CCAAT/enhancer binding protein-beta) cooperate to regulate the murine StAR (steroidogenic acute regulatory) promoter. Mol Endocrinol 13, 729-741. 

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