Steroidogenic acute regulatory

DHT Dihydrotestosterone StAR Steroidogenic acute regulatory (protein)... 

CBP is predicted by PSORT analysis to be a cytoplasmic protein (Horton et al. 2007) and to contain a steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain of 200 amino acids at its C-terminus (Figure 24.2a). 

Alpy, F., Stoeckel, M. E., Dierich, A. et al. 2001. The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. J. Biol. Chem., 276(6) 4261-4269. 

Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. 1997. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A., 94(21) 11540-11545. 

Miller, W. L. 2007. Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta, 1771(6) 663-676. 

An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22 10613-10620. 

In the animal body three important groups of hormones are formed by the metabolism of cholesterol the progestins, the sex hormones, and the adrenal cortical hormones 249 Their synthesis occurs principally in mitochondria of the adrenal cortex and the gonads. Steroid hormone synthesis is regulated by hormones, such as corticotropin (ACTH), from the anterior pituitary250 (see Chapter 30) and is also dependent upon the recently discovered steroidogenic acute regulatory protein, which in some way promotes the movement of stored cholesterol into mitochondrial membranes.251 252 Some major pathways of... 

Kohen P, Castro O, Palomino A, et al. The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase. J Clin Endocrinol Metab. 2003 88 3421-3430. 

Lin D, SugawaraT, Strauss JF 3rd, et al. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267 1821-... 

Tuckey RC, Headlam MJ, Bose HS, Miller WL Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR). f Biol Chem 277 47123-47128,2002. 

The initial rate limiting step in the transport of intracellular cholesterol to sites of steroidogenesis is mediated by a steroidogenic acute regulatory protein (StAR) that is regulated by adrenocorticotropic hormone (ACTH). 

Bauer, M.P., J.T. Bridgham, D.M. Langenau, A.L. Johnson and F.W. Goetz. Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates. Mol. Cell. Endocrinol. 168 119-125, 2000. 

Kusakabe, M., T. Todo, H.J. McQuillan, F.W. Goetz and G. Young. Characterization and expression of steroidogenic acute regulatory protein and MLN64 cDNAs in trout. Endocrinology 143 2062-2070, 2002. 

Walsh, L.P., C. McCormick, C. Martin and D.M. Stocco. Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ. Health Perspect. 108 769-776, 2000. 

Walsh, L.P. and D.M. Stocco. Effects of lindane on steroidogenesis and steroidogenic acute regulatory protein expression. Biol. Reprod. 63 1024-1033, 2000. 

N3Br2DD 2-azido-3-iodo-7,8-dibromodibenzo-p- StAR steroidogenic acute regulatory... 

One well-established component of the intracellular cholesterol-transport system Is the steroidogenic acute regulatory (StAR) protein. This protein, which is encoded in nuclear DNA, controls the transfer of cholesterol from the cholesterol-rich outer mitochondrial membrane to the cholesterol-poor Inner membrane, where it undergoes the first steps in its enzymatic conversion into steroid hormones. StAR-mediated cholesterol transport Is a key regulated, ratecontrolling step in steroid hormone synthesis. StAR contains... 

Clark, B. J., and Combs, R. (1999). Angiotensin II and cyclic adenosine 3 ,5 -monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element. Endocrinology 140, 4390-4398. 

Clem, B. F., Hudson, E. A., and Clark, B. J. (2005). Cyclic adenosine 3 ,5 -monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 3, 1348-1356. 

Necrosis Factor- alpha and Ceramide Directly Abrogates Steroidogenic Acute Regulatory Protein Expression and Leydig Cell Steroidogenesis in Adult Rats. Endocrinology 144, 4763 772. 

Ramnath, H. I., Peterson, S., Michael, A. E., Stocco, D. M., and Cooke, B. A. (1997). Modulation of steroidogenesis by chloride ions in MA-10 mouse tumor Leydig cells roles of calcium, protein synthesis, and the steroidogenic acute regulatory protein. Endocrinology 138, 2308-2314. 

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