Steroid receptor binding

Inhaled corticosteroids are the preferred long-term control therapy for persistent asthma in all patients because of their potency and consistent effectiveness they are also the only therapy shown to reduce the risk of death from asthma. Comparative doses are included in Table 80-3. Most patients with moderate disease can be controlled with twice-daily dosing some products have once-daily dosing indications. Patients with more severe disease require multiple daily dosing. Because the inflammatory response of asthma inhibits steroid receptor binding, patients should be started on higher and more frequent doses and then tapered down once control has been achieved. The response to inhaled corticosteroids is delayed symptoms improve in most patients within the first 1 to 2 weeks and reach maximum improvement in 4 to 8 weeks. Maximum improvement in FEVj and PEF rates may require 3 to 6 weeks. 

Mechanism of action - Classic-steroid receptor binding unit to DNA... 

Recent X-ray studies of enzymes for which steroids are primary substrates, steroid binding globulins, and fragments of steroid receptors with amino acids and nucleic acids are just beginning to provide additional insight into the nature of steroid receptor binding and macromolecular interactions, and the mechanism by which steroids exert their hormonal functions. 

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