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Stereochemical Complexity—Clearable Stereocenters

Some examples of directly clearable (CL) and non-clearable (nCL) stereocenters with respect to a particular transform follow. [Pg.53]

Relationships between stereocenters vary between two extremes. On the one hand, stereocenters may interact strongly in a spatial sense if they are directly joined, proximate to one another, or part of a compact rigid-ring structure. On the other hand, two stereocenters which are remote from one another and/or flexibly connected may be so independent that one cannot be used to provide substrate spatial control for the other. Nonetheless, this latter type of stereorelationship may still be clearable if the target molecule can be disconnected to divide the two stereocenters between two precursors or if an appropriate enantioselective transform is available. [Pg.54]

When stereochemical complexity is embedded in topological complexity, such as in complex polycyclic structures, the stereochemical strategies which are most effective are those which are linked to both complexities. A decidedly different strategic approach is appropriate for topologically simpler systems. [Pg.54]

See other pages where Stereochemical Complexity—Clearable Stereocenters is mentioned: [Pg.47]    [Pg.51]    [Pg.58]    [Pg.62]    [Pg.51]    [Pg.447]    [Pg.47]    [Pg.51]    [Pg.58]    [Pg.62]    [Pg.51]    [Pg.447]    [Pg.51]    [Pg.56]    [Pg.84]    [Pg.62]    [Pg.67]    [Pg.93]    [Pg.51]    [Pg.56]    [Pg.84]    [Pg.81]    [Pg.83]    [Pg.90]    [Pg.92]    [Pg.81]    [Pg.83]   


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