Step 5 System integration

Other steps are no different to any quality system development and further guidance is given in Part 2 of this handbook and in the ISO 9000 Quality S /stem Development Handbook. 

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Training of the data collectors is an important step in ensuring reliable data collection. Trainees will have different levels of computer competency but all must be comfortably competent with the system before data collection can start. Entry of practice data for each form is recommended during training. Strict guidelines for the use of the trial computer hardware and software must be established at the outset to ensure system integrity. Table 25.2 illustrates a list of these guidelines. 

The schemes considered are only a few of the variety of combinations of consecutive first-order and second-order reactions possible including reversible and irreversible steps. Exact integrated rate expressions for systems of linked equilibria may be solved with computer programs. Examples other than those we have considered are rarely encountered however except in specific areas such as oscillating reactions or enzyme chemistry, and such complexity is to be avoided if at all possible. 

Electronic complexity reduction may provide an alternative method for sequence enrichment that is rapid, user-friendly and potentially quantitative. The device used in this experiment permits very high current densities and thus allows transport in buffers other than those typically used for electrophoresis. Beyond the use in complexity reduction, this device, with its ability to sustain high current densities, may have application in hybridization assays with a limited number of probes, immunoassays or other protein-binding reactions, and cell transport studies. Furthermore, the use of electrophoretic transport through all of the steps from sample processing through the assay should facilitate systems integration. 

The development of the HySPP is a crucial step in the scale-up of the HyS technology. This will build on the HyS component development and R D project. The HySPP is also an important risk mitigation tool as supplier (and supply chain) evaluation, system integration, human capital development, scale-up verification, proof of concept, materials of construction verification and various other risks will be mitigated before proceeding with basic and detail design of the commercial HyS plant. 

Similiar problems are known in classical MD simulations, where intramolecular and intermolecular dynamics evolve on different time scales. One possible solution to this problem is the method of multiple time scale propagators which is describede in section 5. Berne and co-workers [21] first used different time steps to integrate the intra- and intermolecular degrees of freedom in order to reduce the computational effort drastically. The method is based on a Trotter-factorization of the classical Liouville-operator for the time evolution of the classical system, resulting in a time reversible propagation scheme. The multiple time scale approach has also been used to speed up Car-Parrinello simulations [20] and ab initio molecular dynamics algorithms [21]. 

This article gives practical validation steps for two types of computer systems integrated computerized analytical systems and a network for file printing and archiving. 

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