Hypotension stem cells

In preparation for bone marrow transplantation, autologous hemopoietic stem cells are normally frozen in liquid nitrogen after harvesting. However, a cryoprotective agent is required, and dimethylsulfoxide is normally used. During and immediately after stem cell infusion, many adverse effects, which may be severe or life-threatening, have been reported. They include hypotension and hjrpertension, anaphylactic reactions, and cardiac and respiratory failure, all possibly due to dimethylsulfoxide, hemolysis induced by cryopreservation and thawing, and fluid overload. 

Morus wittiorum Hand.-Mazz. (stem bark) Diels-Alder type adducts Wittiorumin G (412) albafuran C (427) sorocein A (437) mulberrofuran E (426) mulberrofuran F (430) mulberrofuran O (428). Antioxidant activity, and cytotoxicity against five human cancer cell lines. Mulberrofuran F is a hypotensive Diels-Alder type adduct. Tan et al., 2009[268]. 

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