Stelletta

Fusetani N, Asai N, Matsunaga S, Honda K, Yasumuro K. (1994) Bioactive marine metabolities. 59. CyclosteUettamines A-F, pyridine alkaloids which inhibit binding of methyl quinuclidinyl benzylate (QNB) to muscarinic acetylcholine receptors, from the marine sponge, Stelletta maxima. Tetrahedron Lett 35 3967-3970. 

Guerriero, A. Debitus, C. Pietra, F. (1991) On the first stignmstane sterols and sterones having 24,25-double bond. Isolatimi fix n the sponge Stelletta sp. of deq Coral Sea. Helv. Chim. Acta, 74, 487-94. 

Matsunaga, S. Yamashita, T. Tsukamoto, S. Fusaani, N. (1999) Three new antibactoial alkaloids from a marine sponge Stelletta species. J. Nat. Prod., 62, 1202-4. 

Stellettadine A (100), which is isolated from a sponge Stelletta sp., represents the first polyamine alkaloid with an arcaine backbone (32). Similar alkaloids [e.g., steUettazole A (101)] are also known from the same source. These compounds show larval... 

Only a few compounds of these classes of alkaloids have been reported from marine organisms. Clavepictine B (107), which was isolated from the ascidian Clavelinapicta, is marginally cytotoxic. Stellettamine A (108), which is an indolizidine derivative from a sponge Stelletta sp., is antifungal and cytotoxic. It... 

Bioassay-guided fractionation of an aqueous extract from a Philippine Islands collection of the soft coral Lohophytum spp. yielded cembranoid diterpenes, Fig. (3), which exhibited moderate HIV-inhibitory activity in a cell-based in vitro anti-HIV assay [44], while new isomalabaricane triterpenes. Fig. (4), have been isolated from the sponge Stelletta spp. [45]. Other anti-HIV diterpenes also included the dolabellane diterpenes isolated from the Brazilian brown algae Dictyota pfaffi [46] and Dictyota menstrualis [47]. To investigate the effect of these diterpenes in the reverse transcription of the viral genomic RNA, the recombinant HIV-1 RT was assayed in vitro in the presence of each compound. All compounds inhibited the RNA-dependent DNA-polymerase activity of HIV-1 RT and consequently virus replication. 

Cyclic dimeric 3-APs are exemplified by cyclostellettamines (53-63), Fig. (14), and dihydrocyclostellettamines (64, 65), Fig. (15). These compounds have been isolated from a different collection of sponges, Stelletta maxima (most probably from its encrusted contaminant -Haliclona ) [23], Xestospongia sp. [24], 2Lnd Pachychalina sp. [25]. 

B/S-MACROCYCLES cyclostellettamines A(38) - F(43) Stelletta maxima [30] Van Soest = Haliclona sp. Chalinidae... 

Stellettamide A (99), an unusual indolizidine alkaloid originally isolated from Stelletta sp. as an antifungal and cytotoxic compound,was found to inhibit Ca /calmodulin-dependent phosphodiesterase and... 

Cyclostelletamines A—F (37-42). Isolated from the sponge Stelletta maxima [38], these compounds are biogenetically related to hditoxin (35) and the polymeric 1,3-dialkyIpiridinium salts of 36. Their structures were deduced by HRFABMS and FAB-MS/MS studies. 37-42 block the binding site of Methyl Quinuclidin Benzilate (QNB) to different muscarinic receptor subtypes. In order to confirm the proposed structure, the most abundant metabolite in the sponge, cyclostelletamine C (39), was synthesized by the stepwise ring closure method via 3-(13-... 

Cyclostellettamines A-F, Pyridine Alkaloids which Inhibit Binding of Methyl Quinuclidinyl Benzilate (QNB) to Muscarinic Acetylcholine Receptors, from the Marine Sponge Stelletta maxima. Fusetani, N. Asai, N. Honda, K. and Yasumuro, K. Tetrahedron Lett, 1994, 35, 3967. 

McCabe T, Clardy J, Minale L, Pizza C, Zollo F, Riccio R 1982 A triterpenoid pigment with the isomalabaricane skeleton from the marine sponge Stelletta sp. Tetrahedron Lett 23 3307-3310... 

McCabe, T., J. Clardy, L. Minale, C. Pizza, F. Zollo, and R. Riccio A Triterpenoid Pigment with the Isomalabaricane Skeleton from the Marine Sponge Stelletta sp. Tetrahedron Lett. 23, 3307 (1982). 

This olefination strategy has been used by Kobayashi to synthesize globostellatic acid analogs, an antiangiogenic triterpene derivative from the marine sponge Stelletta globostellata (Fig. 14) [57]. Thus ketone 44 is olefinated by ynolate to yield the tetrasubstituted olefin 45. 

Psychrobacter sp. Sponge, Stelletta sp. Indole oligomers L-Trl, Sym-Tetra Siderophore Li H etal., 2010... 

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