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STATs prolactin

Cytokine receptors that couple to the JAK-STAT Pathway decode the signaling though hematopoietic cytokines (erythropoietin, thrombopoietin, colony-stimulating factors), prolactin, growth hormone, the a-, (3- and y- interferons, and a number of immunomodulatory interleukins [3], They form homodimetic or heterodimeric receptor complexes, which after ligandbinding recruit and activate isotypes of Janus kinases (JAKs). Activated JAKs in turn... [Pg.1238]

AII of these hormones act through G protein-coupled receptors except growth hormone and prolactin, which act through JAK/STAT receptors. [Pg.825]

Not all receptors may be expressed in the same cell. A case in question is the restricted, cell-specific expression of receptors for IL-2, erythropoietin, thrombo-poietin, prolactin, and growth hormone, all of which activate the same STAT. [Pg.116]

These JAK/STAT-coupled receptors concern the effects of cytokines the growth hormone somatotropin (GH), erythropoietin (EPO), prolactin (PRL), granulocyte-colony-stimulating-factor (G-CSF), granulocyte and macrophage-colony-stimulating-factor (GM-CSF), leptin, thrombopoi-etin, interferons a, 3 and % and interleukins 2, 3,4, 5, 6, 7, 9,10 and 15. [Pg.97]

Various other stimuli have been shown to activate the STATs in neutrophils. Amongst them, prolactin was shown to promote the tyrosine phosphorylation of STATl, and to induce the formation of a specific GAS-binding complex in EMSA [63]. The nature of the complex remains uncertain, as supershift assays were inconclusive a probable reason for this outcome is that neutrophil extracts were prepared using a detergent-based kit [63]. Nevertheless, prolactin rapidly induced the expression of SOCS-2 and IRF-1 in neutrophils... [Pg.8]


See other pages where STATs prolactin is mentioned: [Pg.436]    [Pg.467]    [Pg.467]    [Pg.825]    [Pg.56]    [Pg.189]    [Pg.336]    [Pg.607]    [Pg.969]   
See also in sourсe #XX -- [ Pg.8 ]




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